Myelodysplastic syndrome associated with trisomy 2

Summary Clinical course and cytogenetic analysis suggest that myelodysplasia (MDS) is one step in a multistep model of malignant transformation of haematopoietic stem cells to acute myeloid leukaemia (AML). We report a further case of MDS associated with trisomy 2, and comment on the significance of...

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Bibliographic Details
Published inClinical and laboratory haematology Vol. 27; no. 4; pp. 270 - 273
Main Authors HELLER, M., PROVAN, D., AMESS, J. A. L., DIXON‐MCIVER, A.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Science Ltd 01.08.2005
Subjects
acute myeloid leukaemia
Aged
Chromosome Aberrations
Chromosomes, Human, Pair 2 - genetics
Humans
In Situ Hybridization, Fluorescence
Male
multistep model of cancer
Myelodysplasia
Myelodysplastic Syndromes - genetics
Trisomy - diagnosis
Trisomy - genetics
trisomy 2
unbalanced chromosomal abnormality
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Summary:Summary Clinical course and cytogenetic analysis suggest that myelodysplasia (MDS) is one step in a multistep model of malignant transformation of haematopoietic stem cells to acute myeloid leukaemia (AML). We report a further case of MDS associated with trisomy 2, and comment on the significance of the cytogenetic abnormality, which as a sole abnormality only occurs in MDS, but is found in combination with other chromosomal abnormalities in AML. Previous reports on balanced and unbalanced chromosomal abnormalities associated with therapy related MDS and therapy related AML suggest that trisomy 2 is an early chromosomal abnormality in leukaemogenesis.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:0141-9854
1365-2257
DOI:10.1111/j.1365-2257.2005.00694.x