Nocardia Infections in the Immunocompromised Host: A Case Series and Literature Review

Nocardia is primarily considered an opportunistic pathogen and affects patients with impaired immune systems, solid-organ transplant recipients (SOTRs), and patients with haematologic malignancies. We present the cases of six patients diagnosed with nocardiosis at our center in the last two years, d...

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Published inMicroorganisms (Basel) Vol. 10; no. 6; p. 1120
Main Authors Palomba, Emanuele, Liparoti, Arianna, Tonizzo, Anna, Castelli, Valeria, Alagna, Laura, Bozzi, Giorgio, Ungaro, Riccardo, Muscatello, Antonio, Gori, Andrea, Bandera, Alessandra
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 29.05.2022
MDPI
Subjects
Abscesses
Antibiotics
Biopsy
Case Report
Disease prevention
haematologic malignancies
Hematopoietic stem cells
Hepatitis
Immune system
immunocompromised
Infections
Literature reviews
Lungs
Magnetic resonance imaging
Medical imaging
Nocardia
Nocardiosis
Opportunist infection
Patients
Prophylaxis
Risk analysis
Risk factors
SOT
Stem cell transplantation
Stem cells
Steroids
Tomography
transplant
Transplantation
Transplants & implants
Ultrasonic imaging
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Summary:Nocardia is primarily considered an opportunistic pathogen and affects patients with impaired immune systems, solid-organ transplant recipients (SOTRs), and patients with haematologic malignancies. We present the cases of six patients diagnosed with nocardiosis at our center in the last two years, describing the various predisposing conditions alongside the clinical manifestation, the diagnostic workup, and the treatment course. Moreover, we propose a brief literature review on Nocardia infections in the immunocompromised host, focusing on SOTRs and haematopoietic stem cell transplantation recipients and highlighting risk factors, clinical presentations, the diagnostic tools available, and current treatment and prophylaxis guidelines.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms10061120