Plasma volume treated with double filtration plasmapheresis and outcomes of acute antibody‐mediated rejection in kidney transplant recipients: A retrospective cohort study

• Published in: Therapeutic apheresis and dialysis Vol. 25; no. 3; pp. 341 - 349
• Main Authors: Noppakun, Kajohnsak, Kittipanyaworakun, Thanapat, Ruengorn, Chidchanok, Vongsanim, Surachet, Saikam, Anchalee, Khamlueang, Nikhom
• Format: Journal Article
• Language: English
• Published: Kyoto, Japan John Wiley & Sons Australia, Ltd 01.06.2021
• Subjects: antibody‐mediated rejection; apheresis; double filtration plasmapheresis; kidney transplantation; therapeutic plasma exchange; therapeutic plasma exchange; double filtration plasmapheresis; apheresis; kidney transplantation; antibody-mediated rejection
• ISSN: 1744-9979; 1744-9987
• DOI: 10.1111/1744-9987.13560

A retrospective cohort study was conducted to evaluate the association between the plasma volume treated by double filtration plasmapheresis and allograft outcomes for the treatment of acute antibody‐mediated rejection in kidney transplant recipients. Patients were divided into two groups: group 1, plasma volume treated between 1 and <1.3 total plasma volume and group 2, plasma volume treated ≥1.3 total plasma volume. Primary outcome was ≥50% reduction of serum creatinine rising from baseline value at 1 month. A total of 32 courses (146 sessions) of double filtration plasmapheresis were performed; 17 and 15 courses in group 1 and group 2, respectively. Primary outcome occurred in 41% of group 1 and 40% of group 2 (adjusted risk ratio 1.15 [95%CI, 0.48‐2.76]). Graft loss at 1 year did not differ between the two groups (adjusted hazard ratio 0.65 [95%CI, 0.23‐1.87]). Infection tendency seemed to be higher in group 2 (40% vs 18%, P = .243).