Long-term prognostic significance of homocysteine in middle-aged and elderly

• Published in: Biomarkers Vol. 21; no. 6; pp. 490 - 496
• Main Authors: Petersen, Julie Falkenberg, Larsen, Bjørn Strøjer, Sabbah, Muhammad, Nielsen, Olav Wendelboe, Kumarathurai, Preman, Sajadieh, Ahmad
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.08.2016
• Subjects: Aged; All-cause mortality; Biomarkers - blood; cardiovascular disease; Cardiovascular Diseases - blood; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - mortality; Disease-Free Survival; Female; Follow-Up Studies; Homocysteine - blood; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; plasma homocysteine; Prognosis; Proportional Hazards Models; Risk Factors; cardiovascular disease; plasma homocysteine; All-cause mortality
• ISSN: 1354-750X; 1366-5804
• DOI: 10.3109/1354750X.2016.1160288

Objective: We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events. Methods: Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years. Results: Subjects with Hcy ≥ 10.8 μmol/l (n = 231) had a significant higher incidence of all-cause mortality (p < 0.001) and CV events (p < 0.001) compared with subjects with Hcy < 10.8 μmol/l (n = 439). However, there was no association on high levels of Hcy and VTE events or stroke. Conclusion: Increased levels of Hcy are associated with all-cause mortality and CV events.