Oral indigo carmine for the detection of colon adenoma

• Published in: Scandinavian journal of gastroenterology Vol. 56; no. 3; p. 351
• Main Authors: Kawanishi, Koki, Maekita, Takao, Ikeda, Yoshifumi, Furotani, Masahiko, Tsuboi, Sayaka, Kanno, Takayuki, Niwa, Toru, Nagaoka, Tsunehiro, Tabata, Yoshinari, Hatamaru, Keiichi, Iguchi, Mikitaka, Kitano, Masayuki
• Format: Journal Article
• Language: English
• Published: England 04.03.2021
• Subjects: Adenoma - diagnosis; Cecum; Colon; Colonoscopy; Colorectal Neoplasms; Humans; Indigo Carmine; Prospective Studies; Retrospective Studies; mean adenoma per patient; Adenoma detection rate; colorectal cancer; indigo carmine; colonoscopy
• ISSN: 1502-7708
• DOI: 10.1080/00365521.2020.1867897

Colonoscopy is currently considered the optimal method to detect colorectal neoplasia; however, some adenomas remain undetected. While indigo carmine staining with a dye-spray catheter has demonstrated promising results for reducing the miss rate, we investigated the oral indigo carmine method. The aim of this study was to determine whether oral indigo carmine intake before standard colonoscopy increases the adenoma (and adenocarcinoma) detection rate (ADR) or the mean number of adenomas per patient (MAP). The oral indigo carmine method was performed from April 2018 to July 2020 in two hospitals. Data were collected in a prospective manner and compared to the conventional group whose data were collected retrospectively and consecutively from January 2016 to March 2018. All data were anonymized. Among the 704 patients included, colonoscopies were completely performed in 693 patients (347 in the indigo group). The ADR did not significantly differ between the groups: 42.3% vs. 40.3% (indigo vs. conventional group; odds ratio: 1.13; 95% confidence interval: 0.9-1.33,  = .33). The MAP was significantly greater in the indigo group (1.15) than that in the conventional group (0.82;  = .009). The cecal intubation rate and time to cecal intubation did not differ between the indigo and conventional group (98.6% vs. 98.3%,  = .83, and 6.2 min vs. 5.9 min,  = .39, respectively). The routine use of oral indigo carmine does not lead to a higher ADR despite the higher MAP.