The relation between the ghrelin receptor and FOXP3 in bladder cancer

Immune responses play an important role in the fate of bladder cancer tumors. Treg cells are immunosuppressive and down-regulate the proliferation of effector T cells, which favor tumor survival. Ghrelin is a hormone that stimulates release of growth hormone and anti-inflammatory response to cancer...

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Published inBiotechnic & histochemistry Vol. 96; no. 4; pp. 287 - 295
Main Authors Karimi, Monireh, Heshmati, Masoud, Fattahi, Soheila, Bagheri, Nader, Alibeigi, Faramarz Mohammad, Taheri, Fatemeh, Anjomshoa, Maryam, Jami, Mohammad-Saeid, Ghatreh Samani, Mahdi
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 19.05.2021
Subjects
Bladder cancer
FOXP3
GHS-R1a
human
Treg cells
GHS-R1a
Treg cells
Bladder cancer
FOXP3
human
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Summary:Immune responses play an important role in the fate of bladder cancer tumors. Treg cells are immunosuppressive and down-regulate the proliferation of effector T cells, which favor tumor survival. Ghrelin is a hormone that stimulates release of growth hormone and anti-inflammatory response to cancer cells. Ghrelin also is a gastrointestinal hormone that regulates immune responses via the growth hormone secretagogue receptor (GHS-R1a). The relation among ghrelin, its receptor, and Treg cells that surround bladder tumors is not clear. We found that Foxp3 + T and GHS-R1a cells are increased significantly in bladder tumor tissues. Therefore, we suggest that ghrelin may increase the number of Treg cells in the tumor and suppress activity of the immune system against bladder cancer.
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ISSN:1052-0295
1473-7760
DOI:10.1080/10520295.2020.1799074