Determination of Matrix Metalloproteinase 2 in Biological Samples Using a 3D Stochastic Microsensor Based on Graphene Oxide/AuNanoparticles/(Z)-N-(pyridin-4-yl-methyl) Octadec-9-enamide

The levels of the MMPs in the biological samples of confirmed patients with gastric cancer are significantly elevated compared to those found in healthy people. Therefore, a novel 3D stochastic microsensor based on graphene oxide, modified with gold nanoparticles and (Z)-N-(pyridin-4-yl-methyl) octa...

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Published inInternational journal of molecular sciences Vol. 25; no. 12; p. 6720
Main Authors Cioates Negut, Catalina, Ilie-Mihai, Ruxandra-Maria, Stefan-van Staden, Raluca-Ioana
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 18.06.2024
MDPI
Subjects
biological samples
Biomarkers
Biosensing Techniques - methods
Cancer
Carbon
Gastric cancer
Gold - chemistry
Graphene
Graphite - chemistry
Growth factors
Humans
Investigations
Matrix Metalloproteinase 2 - blood
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 2 - urine
Metal Nanoparticles - chemistry
MMP-2
Morphology
Motility
Nanoparticles
Quantitative analysis
Sensors
Stomach Neoplasms - blood
Stomach Neoplasms - diagnosis
three-dimensional stochastic microsensor
Tumors
three-dimensional stochastic microsensor
MMP-2
gastric cancer
biological samples
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Abstract The levels of the MMPs in the biological samples of confirmed patients with gastric cancer are significantly elevated compared to those found in healthy people. Therefore, a novel 3D stochastic microsensor based on graphene oxide, modified with gold nanoparticles and (Z)-N-(pyridin-4-yl-methyl) octadec-9-enamide (namely N2-AuNP/GO), was designed for the determination of MMP-2 in biological samples, and validated for the screening tests of biological samples in order to be used for the early diagnosis of gastric cancer. The proposed sensor presents a low limit of quantification (1.00 × 10 g mL ), high sensitivity (1.84 × 10 s g mL), and a wide working concentration range (1.00 × 10 -1.00 × 10 g mL ). Recovery values higher than 99.15% were recorded for the assay of MMP-2 in whole blood, gastric tissue tumors, saliva, and urine samples.
AbstractList The levels of the MMPs in the biological samples of confirmed patients with gastric cancer are significantly elevated compared to those found in healthy people. Therefore, a novel 3D stochastic microsensor based on graphene oxide, modified with gold nanoparticles and (Z)-N-(pyridin-4-yl-methyl) octadec-9-enamide (namely N2-AuNP/GO), was designed for the determination of MMP-2 in biological samples, and validated for the screening tests of biological samples in order to be used for the early diagnosis of gastric cancer. The proposed sensor presents a low limit of quantification (1.00 × 10−22 g mL−1), high sensitivity (1.84 × 107 s−1 g−1 mL), and a wide working concentration range (1.00 × 10−22–1.00 × 10−7 g mL−1). Recovery values higher than 99.15% were recorded for the assay of MMP-2 in whole blood, gastric tissue tumors, saliva, and urine samples.
The levels of the MMPs in the biological samples of confirmed patients with gastric cancer are significantly elevated compared to those found in healthy people. Therefore, a novel 3D stochastic microsensor based on graphene oxide, modified with gold nanoparticles and (Z)-N-(pyridin-4-yl-methyl) octadec-9-enamide (namely N2-AuNP/GO), was designed for the determination of MMP-2 in biological samples, and validated for the screening tests of biological samples in order to be used for the early diagnosis of gastric cancer. The proposed sensor presents a low limit of quantification (1.00 × 10 g mL ), high sensitivity (1.84 × 10 s g mL), and a wide working concentration range (1.00 × 10 -1.00 × 10 g mL ). Recovery values higher than 99.15% were recorded for the assay of MMP-2 in whole blood, gastric tissue tumors, saliva, and urine samples.
The levels of the MMPs in the biological samples of confirmed patients with gastric cancer are significantly elevated compared to those found in healthy people. Therefore, a novel 3D stochastic microsensor based on graphene oxide, modified with gold nanoparticles and (Z)-N-(pyridin-4-yl-methyl) octadec-9-enamide (namely N2-AuNP/GO), was designed for the determination of MMP-2 in biological samples, and validated for the screening tests of biological samples in order to be used for the early diagnosis of gastric cancer. The proposed sensor presents a low limit of quantification (1.00 × 10-22 g mL-1), high sensitivity (1.84 × 107 s-1 g-1 mL), and a wide working concentration range (1.00 × 10-22-1.00 × 10-7 g mL-1). Recovery values higher than 99.15% were recorded for the assay of MMP-2 in whole blood, gastric tissue tumors, saliva, and urine samples.The levels of the MMPs in the biological samples of confirmed patients with gastric cancer are significantly elevated compared to those found in healthy people. Therefore, a novel 3D stochastic microsensor based on graphene oxide, modified with gold nanoparticles and (Z)-N-(pyridin-4-yl-methyl) octadec-9-enamide (namely N2-AuNP/GO), was designed for the determination of MMP-2 in biological samples, and validated for the screening tests of biological samples in order to be used for the early diagnosis of gastric cancer. The proposed sensor presents a low limit of quantification (1.00 × 10-22 g mL-1), high sensitivity (1.84 × 107 s-1 g-1 mL), and a wide working concentration range (1.00 × 10-22-1.00 × 10-7 g mL-1). Recovery values higher than 99.15% were recorded for the assay of MMP-2 in whole blood, gastric tissue tumors, saliva, and urine samples.
The levels of the MMPs in the biological samples of confirmed patients with gastric cancer are significantly elevated compared to those found in healthy people. Therefore, a novel 3D stochastic microsensor based on graphene oxide, modified with gold nanoparticles and (Z)-N-(pyridin-4-yl-methyl) octadec-9-enamide (namely N2-AuNP/GO), was designed for the determination of MMP-2 in biological samples, and validated for the screening tests of biological samples in order to be used for the early diagnosis of gastric cancer. The proposed sensor presents a low limit of quantification (1.00 × 10 −22 g mL −1 ), high sensitivity (1.84 × 10 7 s −1 g −1 mL), and a wide working concentration range (1.00 × 10 −22 –1.00 × 10 −7 g mL −1 ). Recovery values higher than 99.15% were recorded for the assay of MMP-2 in whole blood, gastric tissue tumors, saliva, and urine samples.
Author Cioates Negut, Catalina
Stefan-van Staden, Raluca-Ioana
Ilie-Mihai, Ruxandra-Maria
AuthorAffiliation Laboratory of Electrochemistry and PATLAB, National Institute for Research and Development in Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021 Bucharest, Romania; negutcatalina79@gmail.com
AuthorAffiliation_xml – name: Laboratory of Electrochemistry and PATLAB, National Institute for Research and Development in Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021 Bucharest, Romania; negutcatalina79@gmail.com
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  givenname: Ruxandra-Maria
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  surname: Ilie-Mihai
  fullname: Ilie-Mihai, Ruxandra-Maria
  organization: Laboratory of Electrochemistry and PATLAB, National Institute for Research and Development in Electrochemistry and Condensed Matter, 202 Splaiul Independentei Str., 060021 Bucharest, Romania
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  givenname: Raluca-Ioana
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Issue 12
Keywords three-dimensional stochastic microsensor
MMP-2
gastric cancer
biological samples
Language English
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Snippet The levels of the MMPs in the biological samples of confirmed patients with gastric cancer are significantly elevated compared to those found in healthy...
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pubmed
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StartPage 6720
SubjectTerms biological samples
Biomarkers
Biosensing Techniques - methods
Cancer
Carbon
Gastric cancer
Gold - chemistry
Graphene
Graphite - chemistry
Growth factors
Humans
Investigations
Matrix Metalloproteinase 2 - blood
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase 2 - urine
Metal Nanoparticles - chemistry
MMP-2
Morphology
Motility
Nanoparticles
Quantitative analysis
Sensors
Stomach Neoplasms - blood
Stomach Neoplasms - diagnosis
three-dimensional stochastic microsensor
Tumors
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Title Determination of Matrix Metalloproteinase 2 in Biological Samples Using a 3D Stochastic Microsensor Based on Graphene Oxide/AuNanoparticles/(Z)-N-(pyridin-4-yl-methyl) Octadec-9-enamide
URI https://www.ncbi.nlm.nih.gov/pubmed/38928425
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https://www.proquest.com/docview/3072804388
https://pubmed.ncbi.nlm.nih.gov/PMC11203526
https://doaj.org/article/255a9296f89d4b60a09334ee1ce431e2
Volume 25
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