Egyptian recommendations for the management of systemic lupus erythematosus: a consensus, evidence-based, clinical practice guidelines for treat-to-target management

• Published in: Egyptian Rheumatology and Rehabilitation Vol. 50; no. 1; pp. 23 - 19
• Main Authors: El Miedany, Yasser, Elhadidi, Khaled, Mahmoud, Geilan Abdelmoneim, Abu-Zaid, Mohammed Hassan, Mahmoud, Atef Abdelazim, El Gaafary, Maha, Kamel, Nadia, Fathi, Nihal Ahmed, Nasser, Ahmed Abdel, Hassan, Waleed, Eissa, Mervat, Sarhan, Eman, Aboalfadl, Essam, Mansour, Ahmed Ezzat, Mortada, Mohamed, Fouad, Nermeen Ahmed, Elaraby, Ismail, Elnemr, Rehab, Medhat, Basma M., Mohamed, Sally S., Ibrahim, Rehab Ali, Tabra, Samar abd Alhamed, Saber, Sally, Franklin, Genny, Mokbel, Abir
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 06.04.2023; Springer Nature B.V; SpringerOpen
• Subjects: Agreements; Clinical practice guidelines; Delphi method; Discoid lupus erythematosus; Disease; Literature reviews; Lupus; Medical diagnosis; Medicine; Medicine & Public Health; Outcomes; PICO; Quality of life; Questionnaires; Rehabilitation; SLE; Subject heading schemes; Systemic lupus eryhtematosus; Thrombocytopenia; Treat-to-target; Egypt; PICO; Lupus; Egyptian guidelines; Discoid lupus erythematosus; Immunosuppressants; Non-biologics; Assessment; Efficacy; Management; SLE; Outcomes; Treatment; Biologics; Treat-to-target; Diagnosis; Monitoring; Systemic lupus eryhtematosus
• ISSN: 2090-3235; 1110-161X; 2090-3235
• DOI: 10.1186/s43166-023-00187-9

Background Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by having varying clinical presentation, severity, unpredictable course as well as outcomes. Recent disease-modifying conventional and biologic agents have enhanced rates of attaining both short- and long-term management goals, including minimization of glucocorticoid dose and use. This study was carried out to develop an up-to-date evidence-based, consensus on clinical practice guidelines for treat-to-target management of systemic lupus erythematosus in adults. Results The response rate to the online questionnaires, sent to the expert panel who participated in the three rounds, was 95.5%. At the end of round 3, a total of 14 recommendation sections were proposed for the T2T management of patients with SLE. Agreement with the recommendations (rank 7–9) ranged from 90.9–100%. Consensus was reached (i.e., ≥ 80% of respondents strongly agreed or agreed) on the proposed statements. Conclusion These recommendations provide a consensus on the treat-to-target management of patients with SLE. They provide strategies to reach optimal outcomes in common clinical scenarios, based on a combination of evidence and expert opinion.