Production of the radioactive antitumoral cisplatin

This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, sealed in a cadmium capsule. The irradiation of CDDP covered by cadmium, employing exposure times longer than 2 h, demonstrated good chemical purity and high specific activity. This finding allowed a better...

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Published inApplied radiation and isotopes Vol. 64; no. 2; pp. 178 - 181
Main Authors Leal, Alexandre S., Júnior, Álvaro D. Carvalho, Abrantes, Fabiana M., Menezes, Maria Ângela de B.C., Ferraz, Vany, Cruz, Tamara S., Cardoso, Valbert N., de Oliveira, Mônica C.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2006
Subjects
Animals
Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - radiation effects
Cadmium - administration & dosage
Cadmium - chemistry
Cadmium - radiation effects
Carcinoma, Ehrlich Tumor - metabolism
Cisplatin - pharmacokinetics
Cisplatin - radiation effects
Neutron activation
Platinum - radiation effects
Radioisotopes - chemistry
Radioisotopes - pharmacokinetics
Radiolabelled cisplatin
TRIGA research reactor
TRIGA research reactor
Radiolabelled cisplatin
Neutron activation
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Summary:This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, sealed in a cadmium capsule. The irradiation of CDDP covered by cadmium, employing exposure times longer than 2 h, demonstrated good chemical purity and high specific activity. This finding allowed a better detection of in vivo CDDP* and suggests that it may be a good tool for studies of long-term biodistribution of pharmaceutical formulations containing this drug.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2005.07.004