Anti-obesity and lipid lowering effects of Cymodocea nodosa sulphated polysaccharide on high cholesterol-fed-rats

This study aims to evaluate for the first time the effects of Cymodocea nodosa sulphated polysaccharide (CNSP) on lipase activity in vitro and in vivo to high fat diet (HFD)-rats on body weight, lipid profile and liver-kidney functions. The administration of CNSP decreases the body weight and inhibi...

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Bibliographic Details
Published inArchives of physiology and biochemistry Vol. 121; no. 5; pp. 210 - 217
Main Authors Ben Abdallah Kolsi, Rihab, Ben Gara, Amel, Chaaben, Rim, El Feki, Abdelfattah, Paolo Patti, Francesco, El Feki, Lotfi, Belghith, Karima
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 20.10.2015
Subjects
Alismatales - chemistry
Animals
Anti-Obesity Agents - pharmacology
Antioxidants - pharmacology
Body Weight
Catalase - metabolism
Cholesterol - toxicity
Diet, High-Fat - adverse effects
Lipid Metabolism - drug effects
Lipid Peroxidation - drug effects
Lipids - analysis
liver-kidney functions
Male
obesity
Obesity - drug therapy
Obesity - etiology
Obesity - metabolism
Plant Extracts - pharmacology
Plant Leaves - chemistry
Polysaccharide
Polysaccharides - pharmacology
Rats
Rats, Wistar
Sulfhydryl Reagents - chemistry
Superoxide Dismutase - metabolism
Thiobarbituric Acid Reactive Substances - metabolism
Polysaccharide
obesity
liver-kidney functions
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Summary:This study aims to evaluate for the first time the effects of Cymodocea nodosa sulphated polysaccharide (CNSP) on lipase activity in vitro and in vivo to high fat diet (HFD)-rats on body weight, lipid profile and liver-kidney functions. The administration of CNSP decreases the body weight and inhibits lipase activity of obese rats in serum and intestine as compared with untreated HDF-rats. This decrease in lipase activity leads to lipid regulation shown by the decrease of total cholesterol (T-Ch), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) and an increase in high density lipoprotein cholesterol (HDL-C) levels in HFD-rats. Additionally, CNSP administration to HFD-rats induces anti-oxidant activity observed by the increase of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities and the decrease in Thiobarbituric acid reactive substances (TBARS) levels and protects liver-kidney functions proven by a decrease in the levels of toxicity parameters in blood.
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ISSN:1381-3455
1744-4160
DOI:10.3109/13813455.2015.1105266