Circulating S100A8/A9 Levels Reflect Intraocular Inflammation in Uveitis Patients

Purpose: To investigate whether there is an association between circulating S100A8/A9 levels and uveitis activity. Methods: A total of 549 plasma samples were collected from uveitis patients and non-uveitic controls. Results: S100A8/A9 plasma levels were elevated in uveitis patients compared to non-...

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Published inOcular immunology and inflammation Vol. 28; no. 1; pp. 133 - 141
Main Authors Wang, Yu-Qin, Dai, Xiao-Dan, Ran, Yun, Cao, Ying, Lan, Chun-Lin, Guan, Ji-Tian, Liu, Chang, Yang, Feng-Mei, Gan, Yi-Jing, Liu, Bai-Jing, Fang, Ai-Wu, Lin, Dan, Gong, Xian-Hui, Cui, Ren-Zhe, Jin, Zi-Bing, Qu, Jia, Lu, Fan, Chi, Zai-Long
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 02.01.2020
Subjects
Administration, Ophthalmic
Adult
Aged
Biomarker
Biomarkers - blood
Calgranulin A - blood
Calgranulin B - blood
calprotectin
Female
Glucocorticoids - therapeutic use
Humans
Inflammation - blood
Inflammation - drug therapy
Male
Middle Aged
ocular inflammation
Ophthalmic Solutions
S100A8/A9
uveitis
Uveitis - blood
Uveitis - drug therapy
Young Adult
S100A8/A9
Biomarker
ocular inflammation
uveitis
calprotectin
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Summary:Purpose: To investigate whether there is an association between circulating S100A8/A9 levels and uveitis activity. Methods: A total of 549 plasma samples were collected from uveitis patients and non-uveitic controls. Results: S100A8/A9 plasma levels were elevated in uveitis patients compared to non-uveitic controls (P < 0.001). S100A8/A9 plasma levels in patients with active acute anterior uveitis (AAU) were significantly elevated and remarkably decreased in parallel with the severity of intraocular inflammation after corticosteroid treatment (P < 0.001). S100A8/A9 plasma levels were also higher in AAU patients with ankylosing spondylitis (AS) than in patients without AS (P = 0.02). S100A8/A9 plasma levels were significantly increased in uveitis patients with elevated C-reactive protein (CRP, P = 0.004) or erythrocyte sedimentation rates (ESR, P = 0.049) levels compared to uveitis patients with normal CRP or ESR values. Conclusion: Circulating S100A8/A9 might be a useful biomarker for the measurement of intraocular inflammation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0927-3948
1744-5078
DOI:10.1080/09273948.2018.1538461