High-intensity interval training improves inflammatory and adipokine profiles in postmenopausal women with metabolic syndrome

• Published in: Archives of physiology and biochemistry Vol. 125; no. 1; pp. 85 - 91
• Main Authors: Steckling, Flávia Mariel, Farinha, Juliano Boufleur, Figueiredo, Felipe da Cunha, Santos, Daniela Lopes Dos, Bresciani, Guilherme, Kretzmann, Nélson Alexandre, Stefanello, Sílvio Terra, Courtes, Aline Alves, Beck, Maristela de Oliveira, Sangoi Cardoso, Manuela, Duarte, Marta Maria Medeiros Frescura, Moresco, Rafael Noal, Soares, Félix Alexandre Antunes
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2019
• Subjects: adipokines; high-intensity interval training; Metabolic syndrome; mRNA; obesity; high-intensity interval training; adipokines; mRNA; Metabolic syndrome; obesity
• ISSN: 1381-3455; 1744-4160
• DOI: 10.1080/13813455.2018.1437750

This study investigate the effects of high-intensity interval training (HIIT) on systemic levels of inflammatory and hormonal markers in postmenopausal women with metabolic syndrome (MS). Fifteen postmenopausal women with MS completed the training on treadmills. Functional, body composition parameters, maximal oxygen uptake (VO 2 max), and lipid profile were assessed before and after HIIT. Serum or plasma levels of cytokines and hormonal markers were measured along the intervention. The analysis of messenger RNA (mRNA) expression of these cytokines was performed in peripheral blood mononuclear cells (PBMC). VO 2 max and some anthropometric parameters were improved after HIIT, while decreased levels of proinflammatory markers and increased levels of interleukin-10 (IL-10) were also found. Adipokines were also modulated after 12 weeks or training. The mRNA expression of the studied genes was unchanged after HIIT. In conclusion, HIIT benefits inflammatory and hormonal axis on serum or plasma samples, without changes on PBMC of postmenopausal MS patients.