Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function

• Published in: The New England journal of medicine Vol. 312; no. 19; pp. 1217 - 1224
• Main Authors: Lee, Tak H, Hoover, Richard L, Williams, John D, Sperling, Richard I, Ravalese, Joseph III, Spur, Bernd W, Robinson, Dwight R, Corey, E.J, Lewis, Robert A, Austen, K. Frank
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 09.05.1985
• Subjects: ACEITES DE PESCADO; Adult; Arachidonic Acids - metabolism; Biological and medical sciences; Cell Adhesion - drug effects; Chemotaxis, Leukocyte - drug effects; COMPOSICION DE LA SANGRE; COMPOSITION DU SANG; CORPS GRAS; DIETA; Dietary Fats - administration & dosage; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Unsaturated - administration & dosage; Fatty Acids, Unsaturated - blood; Fatty Acids, Unsaturated - pharmacology; Feeding. Feeding behavior; Fish Oils - administration & dosage; Fundamental and applied biological sciences. Psychology; GLICERIDOS; GLYCERIDE; GRASAS; HUILE DE POISSON; Humans; LEUCOCITOS; LEUCOCYTE; Leukotriene B4 - metabolism; Lipids - blood; Lipoxygenase - metabolism; Male; Membrane Fluidity; METABOLISME DES LIPIDES; METABOLISMO DE LIPIDOS; Middle Aged; Monocytes; Monocytes - drug effects; Monocytes - metabolism; Neutrophils - drug effects; Neutrophils - metabolism; Neutrophils - physiology; REGIME ALIMENTAIRE; Triglycerides - administration & dosage; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Human; Blood cell; Oil; Monocyte; Diet; Leukocyte; Inflammation; Supplemented diet; Arachidonic acid; Normal; Fish oil
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM198505093121903

A study demonstrated that a fish-oil supplemented-diet with eicosapentaenoic (ECP) and docosahexaenoic acids for 6 weeks, 1) led to the incorporation of ECP acid into the membrane lipids of neutrophils and monocytes, 2) suppressed the generation of leukotriene B4 by the 5-lipoxygenase pathway, and 3) altered the neutrophil functional responses mediated by this leukotriene. It was concluded that diets supplemented with fish-oil derived fatty acids may have an antiinflammatory effect by inhibiting the 5-lipoxygenase pathway in neutrophils and monocytes, and by inhibiting the leukotriene B4-mediated functions of neutrophils. (wz)