Role of Branched-chain Amino Acid Metabolism in Tumor Development and Progression

Branched-chain amino acids (BCAAs), isoleucine, leucine and valine, are essential amino acids with vital roles in protein synthesis and energy production. We reviewed the fundamentals of BCAA metabolism in advanced cancer patients. BCAAs and various catabolic products act as signalling molecules, wh...

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Published inJournal of cancer prevention Vol. 26; no. 4; pp. 237 - 243
Main Authors Jung, Min Kyu, Okekunle, Akinkunmi Paul, Lee, Jung Eun, Sung, Mi Kyung, Lim, Yun Jeong
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Society of Cancer Prevention 30.12.2021
대한암예방학회
Subjects
Review
예방의학
Neoplasm
Amino acids
branched-chain
Leucine
Valine
Isoleucine
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Summary:Branched-chain amino acids (BCAAs), isoleucine, leucine and valine, are essential amino acids with vital roles in protein synthesis and energy production. We reviewed the fundamentals of BCAA metabolism in advanced cancer patients. BCAAs and various catabolic products act as signalling molecules, which activate mechanisms ranging from protein synthesis to insulin secretion. Recently, BCAA metabolism has been suggested to contribute to cancer progression. Of particular interest is the modulation of the mTOR activity by BCAAs. There are likely multiple pathways involved in BCAA metabolism implicated in carcinogenesis. Understanding the mechanism(s) underlying altered BCAAs metabolism will significantly advance the current understanding of nutrient involvement in carcinogenesis and direct future studies to unravel the significance of BCCA metabolites in tumor development and progression.
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These authors contributed equally and are joint first authors for this work.
ISSN:2288-3649
2288-3657
DOI:10.15430/JCP.2021.26.4.237