Strategies and delivery systems for cell-based therapy in autoimmunity

This review article explores the potential of engineering antigen-presenting cells (APCs) for the immunotherapy of autoimmune diseases. It discusses various strategies for modifying APCs to induce antigen-specific tolerance, thereby mitigating autoimmune responses. The review covers recent advanceme...

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Bibliographic Details
Published inFrontiers in Drug Delivery Vol. 4
Main Authors Puccetti, Matteo, Costantini, Claudio, Schoubben, Aurélie, Giovagnoli, Stefano, Ricci, Maurizio
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 08.08.2024
Subjects
antigen-presenting cells
autoimmunity
Drug Delivery
genetic engineering
immunotherapy
nanoparticles
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Summary:This review article explores the potential of engineering antigen-presenting cells (APCs) for the immunotherapy of autoimmune diseases. It discusses various strategies for modifying APCs to induce antigen-specific tolerance, thereby mitigating autoimmune responses. The review covers recent advancements in APC engineering techniques, including genetic modification and nanoparticle-based approaches, and evaluates their efficacy in preclinical models and clinical trials. Additionally, challenges and future directions for the development of APC-based immunotherapies for autoimmunity – and other forms of cell-based immunotherapy – are discussed. Along this direction, this review ( i ) describes various strategies for engineering APCs, including genetic modification, nanoparticle delivery systems, and ex vivo manipulation techniques; ( ii ) discusses the selection of target antigens and the design of APC-based immunotherapies, and ( iii ) reviews preclinical models used to evaluate the efficacy and safety of engineered APCs in inducing antigen-specific tolerance.
Bibliography:Reviewed by: Taskeen Janjua, The University of Queensland, Australia
Edited by: Cristian Vilos, University of Talca, Chile
Rohit K Sharma, University of California, Berkeley, United States
ISSN:2674-0850
2674-0850
DOI:10.3389/fddev.2024.1436842