AChE mRNA expression as a possible novel biomarker for the diagnosis of coronary artery disease and Alzheimer's disease, and its association with oxidative stress

Oxidative metabolic reactions and their by products have played a role in coronary artery disease (CAD) and Alzheimer's disease (AD) pathogenesis. This study was carried out on 28 patients with AD, 21 patients with CAD, and 28 healthy as control. Oxidative stress biomarkers and acetylcholineste...

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Bibliographic Details
Published inArchives of physiology and biochemistry Vol. 128; no. 2; pp. 352 - 359
Main Authors Işık, Mesut, Beydemir, Şükrü
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 04.03.2022
Subjects
acetylcholinesterase
Acetylcholinesterase - genetics
Acetylcholinesterase - metabolism
Alzheimer Disease - diagnosis
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Alzheimer's disease
Amyloid beta-Peptides - metabolism
Biomarkers - metabolism
Coronary Artery Disease - diagnosis
Coronary Artery Disease - genetics
gene expression
Humans
neurodegenerative disorder
Oxidative Stress
RNA, Messenger - genetics
RNA, Messenger - metabolism
acetylcholinesterase
neurodegenerative disorder
Alzheimer’s disease
gene expression
oxidative stress
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Summary:Oxidative metabolic reactions and their by products have played a role in coronary artery disease (CAD) and Alzheimer's disease (AD) pathogenesis. This study was carried out on 28 patients with AD, 21 patients with CAD, and 28 healthy as control. Oxidative stress biomarkers and acetylcholinesterase (AChE) activity were assayed in plasma. mRNA expression of AChE was investigated in leukocytes of patients with CAD and AD. Thus, Alzheimer's and coronary artery patients were observed that the protein carbonyl levels and mRNA expression of AChE were increased (p<.05, p<.01, respectively). The plasma total thiol levels were decreased compared to the control group (p<.05). There was a significant relationship between amyloid β (Aβ) accumulation and oxidative stress, cholinergic gene expression. AChE gene expression and protein oxidation were increased in patients with AD and CAD. These results suggest that increased release of AChE from cells produces neurotoxic β-amyloid plaques and may cause neurodegenerative diseases.
ISSN:1381-3455
1744-4160
DOI:10.1080/13813455.2019.1683584