Primary small bowel adenocarcinoma: current view on clinical features, risk and prognostic factors, treatment and outcome

• Published in: Scandinavian journal of gastroenterology Vol. 52; no. 11; p. 1194
• Main Authors: Lech, Gustaw, Korcz, Wojciech, Kowalczyk, Emilia, Słotwiński, Robert, Słodkowski, Maciej
• Format: Journal Article
• Language: English
• Published: England 02.11.2017
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - physiopathology; Adenocarcinoma - therapy; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Carcinogenesis; Chemotherapy, Adjuvant; Digestive System Surgical Procedures; Double-Balloon Enteroscopy; Duodenal Neoplasms - diagnosis; Duodenal Neoplasms - physiopathology; Duodenal Neoplasms - therapy; Early Diagnosis; Humans; Ileal Neoplasms - diagnosis; Ileal Neoplasms - physiopathology; Ileal Neoplasms - therapy; Intestine, Small - pathology; Jejunal Neoplasms - diagnosis; Jejunal Neoplasms - physiopathology; Jejunal Neoplasms - therapy; Lymph Node Excision; Prognosis; Risk Factors; Treatment Outcome; SBA; small bowel; Small bowel adenocarcinoma; chemotherapy; surgery
• ISSN: 1502-7708
• DOI: 10.1080/00365521.2017.1356932

Small bowel adenocarcinoma (SBA) is a rare but increasing cause of gastrointestinal malignancy, being both a diagnostic and therapeutic challenge. The goal of treatment is margin negative resection of a lesion and local lymphadenectomy, followed by modern adjuvant chemotherapy combinations in selected cases. Improved outcomes in patients with SBA are encouraging, but elucidation of mechanisms of carcinogenesis and risk factors as well as improved treatment for this malignancy is very needed.