Value of interim FDG PET/CT for predicting outcome of patients with angioimmunoblastic T-cell lymphoma

• Published in: Leukemia & lymphoma Vol. 58; no. 6; pp. 1341 - 1348
• Main Authors: Moon, Seung Hwan, Lee, Ah Young, Kim, Won-Seog, Kim, Seok Jin, Cho, Young Seok, Choe, Yearn Seong, Kim, Byung-Tae, Lee, Kyung-Han
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 03.06.2017
• Subjects: 18F-FDG; Adult; Aged; Aged, 80 and over; Angioimmunoblastic T-cell lymphoma; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cyclophosphamide - therapeutic use; Doxorubicin - therapeutic use; Female; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Immunoblastic Lymphadenopathy - diagnostic imaging; Immunoblastic Lymphadenopathy - pathology; Kaplan-Meier Estimate; Lymphoma, T-Cell - diagnosis; Lymphoma, T-Cell - drug therapy; Lymphoma, T-Cell - mortality; Male; Middle Aged; Neoplasm Staging; Neovascularization, Pathologic - pathology; Patient Outcome Assessment; PET/CT; Positron Emission Tomography Computed Tomography; Prednisone - therapeutic use; Prognosis; Vincristine - therapeutic use; Angioimmunoblastic T-cell lymphoma; 18F-FDG; prognosis; PET/CT
• ISSN: 1042-8194; 1029-2403; 1029-2403
• DOI: 10.1080/10428194.2016.1236380

Subjects were 45 patients with angioimmunoblastic T-cell lymphoma (AITL) who underwent 2-[ 18 F]-fluoro-2-deoxy-d-glucose (FDG) positron-emission tomography/computed tomography (PET/CT) at baseline and interim after 2-4 cycles. Predictors of progression-free survival (PFS) and overall survival (OS) were assessed. Positive interim PET/CT (Deauville score ≥3) was a significant independent predictor of poor PFS (Hazard ratio, 4.42; p=.028), and showed marginal significance to predict OS (p=.065). Less than 60% decrease in the average change of maximum standardized uptake value normalized by lean body mass (SUL max ) also was a significant independent predictor of poor PFS (Hazard ratio, 12.96; p=.001) and poor OS (Hazard ratio, 24.11; p=.006). Interim PET/CT has a significant prognostic value for predicting PFS and OS in patients with AITL. Deauville score and percent decrease of SUL max have the potential to be useful parameter in classifying patients into good and poor responders.