MicroRNA-661 upregulation in myelodysplastic syndromes induces apoptosis through p53 activation and associates with decreased overall survival

MicroRNA (miRNA) dysregulation contributes to myelodysplastic syndromes (MDS), and apoptosis is one of the pathogenic features of MDS. We investigated the dysregulation of miRNA expression and its biological significance in MDS. We compared the expression profiles of miRNAs encoded by chromosome 8 i...

Full description

Saved in:
Bibliographic Details
Published inLeukemia & lymphoma Vol. 60; no. 11; pp. 2779 - 2786
Main Authors Kang, Seong-Ho, Choi, Ji-Seon
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 19.09.2019
Subjects
apoptosis
dysregulation
MDS
microRNA
pathogenesis
dysregulation
pathogenesis
apoptosis
microRNA
MDS
Online AccessGet full text

Cover

More Information
Summary:MicroRNA (miRNA) dysregulation contributes to myelodysplastic syndromes (MDS), and apoptosis is one of the pathogenic features of MDS. We investigated the dysregulation of miRNA expression and its biological significance in MDS. We compared the expression profiles of miRNAs encoded by chromosome 8 in 65 patients with MDS and 11 controls, and analyzed the in vitro effect of the upregulated miRNA expression. We found that compared to the controls, miR-661 was upregulated by 5.28-fold in patients with MDS. Patients with high miR-661 expression showed significantly decreased overall survival. In vitro study results demonstrated that transfection with a miR-661 mimic induced apoptosis through the activation of p53. These findings suggest that high miR-661 expression can be associated with decreased overall survival and recapitulates apoptosis, the characteristic feature of MDS.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1042-8194
1029-2403
DOI:10.1080/10428194.2019.1608528