Prognostic value of thiol/disulfide homeostasis in symptomatic patients with heart failure

• Published in: Archives of physiology and biochemistry Vol. 127; no. 5; pp. 462 - 467
• Main Authors: Caliskan, Haci Mehmet, Sivri, Serkan, Sokmen, Erdogan, Celik, Mustafa, Ilanbey, Bilal, Ozbek, Sinan Cemgil, Celik, Burak
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.09.2021
• Subjects: Heart failure; left ventricular ejection fraction; mortality; thiol/disulphide homeostasis; Heart failure; mortality; thiol/disulphide homeostasis; left ventricular ejection fraction
• ISSN: 1381-3455; 1744-4160; 1744-4160
• DOI: 10.1080/13813455.2020.1773505

We aimed to examine the role of thiol/disulphide homeostasis (TDH) in heart failure and its stages and the prognosis of heart failure. A total of 140 subjects were included in the study. Total and native thiol levels were higher in the control group compared to the patient groups (p < .001). While the average disulphide/total thiol ratio was similar in groups 1 and 2, it was found to be significantly lower in the control group compared to other groups and significantly higher in group 3 compared to other groups (p < .05). Mean native thiol and total thiol levels were found lower in patients with mortality compared to surviving patients (p < .001). In ROC curve analysis, it was determined that the total thiol level had 81.8% sensitivity and 83.1% specificity, and native thiol level had 81.8% sensitivity and 84.3% specificity. We found that TDH was impaired in favour of disulphide in cases of heart failure.