Effects of fish protein hydrolysate ingestion on endothelial function compared to whey protein hydrolysate in humans

• Published in: International journal of food sciences and nutrition Vol. 71; no. 2; pp. 242 - 248
• Main Authors: Oliveira, Gustavo Vieira de, Volino-Souza, Mônica, Cordeiro, Elisaldo Mendes, Conte-Junior, Carlos Adam, Alvares, Thiago Silveira
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.02.2020
• Subjects: Endothelial function; fish protein; flow-mediated dilatation; nitric oxide; fish protein; nitric oxide; Endothelial function; flow-mediated dilatation
• ISSN: 0963-7486; 1465-3478
• DOI: 10.1080/09637486.2019.1635090

Fish protein-derived bioactive peptides may improve endothelial dysfunction through an antihypertensive and antioxidant effect. However, few studies have evaluated the bioactive peptides effect on vascular function. Therefore, this study investigates the effect of a single dose of fish protein hydrolysate (FPH) or whey protein hydrolysates (WPH) on endothelium-dependent dilation in nine healthy adults. The subjects ingested a single dose (20 g) of FPH, WHP or placebo (PLA). The endothelium-dependent dilation was evaluated by flow-mediated dilatation before and at 30, 60 and 120 min after supplementation. Total antioxidant capacity (TAC) of the FPH and WPH supplements was evaluated by using the Trolox equivalent antioxidant capacity assay. There was a significant increase of endothelium-dependent dilation at 30 min after WPH but not after FPH as compared to PLA. There was a significant great TAC in FPH than WPH supplement. A single dose of FPH was not able to improve endothelium-dependent dilation compared to WPH.