Blood clusterin levels, rs9331888 polymorphism, and the risk of Alzheimer's disease

Variants in the clusterin gene have been associated with Alzheimer's disease (AD) through replicated genome-wide studies, but the underlying mechanisms remain unknown. In this study the association of the AD clusterin common risk polymorphism rs9331888 with blood clusterin levels was tested in...

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Bibliographic Details
Published inJournal of Alzheimer's disease Vol. 29; no. 3; p. 515
Main Authors Xing, Yao-Yao, Yu, Jin-Tai, Cui, Wei-Zhen, Zhong, Xiao-Ling, Wu, Zhong-Chen, Zhang, Qun, Tan, Lan
Format Journal Article
LanguageEnglish
Published Netherlands 01.01.2012
Subjects
Aged
Aged, 80 and over
Alzheimer Disease - blood
Alzheimer Disease - genetics
Analysis of Variance
Clusterin - blood
Clusterin - genetics
Enzyme-Linked Immunosorbent Assay
Female
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study
Humans
Male
Polymorphism, Single Nucleotide - genetics
Psychiatric Status Rating Scales
Risk Factors
RNA, Messenger - metabolism
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Summary:Variants in the clusterin gene have been associated with Alzheimer's disease (AD) through replicated genome-wide studies, but the underlying mechanisms remain unknown. In this study the association of the AD clusterin common risk polymorphism rs9331888 with blood clusterin levels was tested in 104 AD subjects and 104 healthy controls. Blood clusterin levels were significantly elevated in AD patients (p < 0.05). The rs9331888 AD-risk variant was associated with low clusterin mRNA and protein levels in an allele-dose dependent manner in both groups (p < 0.001). This study indicates that the rs9331888 AD-risk variant is associated with low blood clusterin levels.
ISSN:1875-8908
DOI:10.3233/JAD-2011-111844