Alterations in mtDNA, gastric carcinogenesis and early diagnosis

Gastric cancer remains one of the most prevalent cancers in the world. Due to this, efforts are being made to improve the diagnosis of this neoplasm and the search for molecular markers that may be involved in its genesis. Within this perspective, the mitochondrial DNA is considered as a potential c...

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Published inMitochondrial DNA. Part A. DNA mapping, sequencing, and analysis Vol. 30; no. 2; pp. 226 - 233
Main Authors Rodrigues-Antunes, S., Borges, B. N.
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 17.02.2019
Subjects
gastric cancer
Mitochondrial DNA
molecular markers
gastric cancer
molecular markers
Mitochondrial DNA
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Summary:Gastric cancer remains one of the most prevalent cancers in the world. Due to this, efforts are being made to improve the diagnosis of this neoplasm and the search for molecular markers that may be involved in its genesis. Within this perspective, the mitochondrial DNA is considered as a potential candidate, since it has several well documented changes and is readily accessible. However, numerous alterations have been reported in mtDNA, not facilitating the visualization of which alterations and molecular markers are truly involved with gastric carcinogenesis. This review presents a compilation of the main known changes relating mtDNA to gastric cancer and their clinical significance.
ISSN:2470-1394
2470-1408
DOI:10.1080/24701394.2018.1475478