Nickel exposure and plasma levels of biomarkers for assessing oxidative stress in nickel electroplating workers

Context: The mechanism of nickel-induced pathogenesis remains elusive. Objective: To examine effects of nickel exposure on plasma oxidative and anti-oxidative biomarkers. Materials and methods: Biomarker data were collected from 154 workers with various levels of nickel exposure and from 73 controls...

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Published inBiomarkers Vol. 22; no. 5; pp. 455 - 460
Main Authors Tsao, Yu-Chung, Gu, Po-Wen, Liu, Su-Hsun, Tzeng, I-Shiang, Chen, Jau-Yuan, Luo, Jiin-Chyuan John
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 04.07.2017
Subjects
Adult
Antioxidants - analysis
biomarkers
Biomarkers - blood
Catalase - blood
Electroplating
Glutathione - blood
Humans
Nickel
Nickel - adverse effects
Occupational Exposure - analysis
oxidative stress
Oxidative Stress - drug effects
Young Adult
biomarkers
Nickel
oxidative stress
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Summary:Context: The mechanism of nickel-induced pathogenesis remains elusive. Objective: To examine effects of nickel exposure on plasma oxidative and anti-oxidative biomarkers. Materials and methods: Biomarker data were collected from 154 workers with various levels of nickel exposure and from 73 controls. Correlations between nickel exposure and oxidative and anti-oxidative biomarkers were determined using linear regression models. Results: Workers with a exposure to high nickel levels had significantly lower levels of anti-oxidants (glutathione and catalase) than those with a lower exposure to nickel; however, only glutathione showed an independent association after multivariable adjustment. Discussion and conclusion: Exposure to high levels of nickel may reduce serum anti-oxidative capacity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1354-750X
1366-5804
DOI:10.1080/1354750X.2016.1252964