In vitro activity of the chelating agents nitroxoline and oxine against Mycobacterium bovis BCG

The chelating antibiotic nitroxoline (5-nitro-8-hydroxyquinoline) showed a bacteriostatic effect at a concentration of 10 microM for Mycobacterium bovis BCG. At higher concentrations the compound showed moderate cidal activity against growing bacilli. In contrast, its non-nitrated derivative oxine (...

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Bibliographic Details
Published inInternational journal of antimicrobial agents Vol. 18; no. 6; pp. 579 - 582
Main Authors MURUGASU-OEI, B, DICK, T
Format Journal Article
LanguageEnglish
Published London Elsevier 01.12.2001
Amsterdam
New York, NY
Subjects
8-hydroxyquinoline
Animals
Anti-Bacterial Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiseptics
Antitubercular Agents - pharmacology
Biological and medical sciences
Cattle
Medical sciences
Microbial Sensitivity Tests
Mycobacterium bovis
Mycobacterium bovis - drug effects
Nitroquinolines - pharmacology
nitroxoline
Oxyquinoline - pharmacology
Pharmacology. Drug treatments
Mycobacterium bovis
BCG
Quinoline derivatives
In vitro
Biological activity
Antibiotic
Mycobacteriales
Antiseptic
Mycobacteriaceae
Chelating agent
Bacteria
Actinomycetes
Nitroxoline
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Summary:The chelating antibiotic nitroxoline (5-nitro-8-hydroxyquinoline) showed a bacteriostatic effect at a concentration of 10 microM for Mycobacterium bovis BCG. At higher concentrations the compound showed moderate cidal activity against growing bacilli. In contrast, its non-nitrated derivative oxine (8-hydroxyquinoline, MIC=2 microM) reduced the viability of a growing culture rapidly, 5000-fold at a concentration where the nitroxoline was merely bacteriostatic. Both compounds showed appreciable cidal activity against bacilli in their hypoxic dormant state.
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ISSN:0924-8579
1872-7913
DOI:10.1016/S0924-8579(01)00437-X