Synthesis of some novel 6′-(4-chlorophenyl)-3,4′-bipyridine-3′-carbonitriles: assessment of their antimicrobial and cytotoxic activity

• Published in: Zeitschrift für Naturforschung. B, A journal of chemical sciences Vol. 70; no. 11; pp. 783 - 795
• Main Authors: Hussein, Essam M., Al-Shareef, Hossa F., Aboellil, Amany H., Elhady, Heba A.
• Format: Journal Article
• Language: English
• Published: BERLIN De Gruyter 01.11.2015; Walter De Gruyter
• Subjects: antimicrobial activity; ceric ammonium nitrate (CAN); Chemistry; Chemistry, Inorganic & Nuclear; Chemistry, Organic; cytotoxic activity; HEPG2; Physical Sciences; pyridine; Science & Technology; ANTICANCER; SCHIFF-BASES; ONE-POT; pyridine; HEPG2; antimicrobial activity; cytotoxic activity; DERIVATIVES; ANTITUMOR; ceric ammonium nitrate (CAN)
• ISSN: 0932-0776; 1865-7117
• DOI: 10.1515/znb-2015-0065

A series of novel substituted 6′-(4-chlorophenyl)-3,4′-bipyridine-3′-carbonitriles with incorporated pyrazole and/or triazole moieties have been synthesized using 2-(6′-(4-chlorophenyl)-3′-cyano-3,4′-bipyridin-2′-yloxy)acetohydrazide ( ) as starting material. Also, the key intermediate reacted with aromatic aldehydes and tosyl chloride to give the corresponding Schiff bases and tosyl hydrazide derivatives, respectively. The antimicrobial of these newly synthesized compounds was evaluated against as Gram-positive bacteria and as a fungus; some of these compounds such as , , , , , , and showed excellent activities as antimicrobial agents. Moreover, the cytotoxic activity of the most active compounds was assessed in vitro against human tumor liver cancer cell line (HEPG2); compounds , , , and showed potent activities relative to Doxorubicin which was used as a reference standard drug in this study.