Brentuximab vedotin in T-cell lymphoma

• Published in: Expert review of hematology Vol. 12; no. 1; p. 5
• Main Authors: Van Der Weyden, Carrie, Dickinson, Michael, Whisstock, James, Prince, H Miles
• Format: Journal Article
• Language: English
• Published: England 02.01.2019
• Subjects: Antineoplastic Agents, Immunological - pharmacology; Antineoplastic Agents, Immunological - therapeutic use; Brentuximab Vedotin - pharmacology; Brentuximab Vedotin - therapeutic use; Humans; Lymphoma, T-Cell - drug therapy; peripheral T-cell lymphoma; Brentuximab vedotin; antibody-drug conjugate; SGN-35; cutaneous T-cell lymphoma; T-cell lymphoma
• ISSN: 1747-4094
• DOI: 10.1080/17474086.2019.1558399

Brentuximab vedotin is an antibody-drug conjugate, which combines a CD30 monoclonal antibody with the microtubule-disrupting agent monomethylauristatin E. The utility of brentuximab vedotin has been explored in a number of diseases, with a recent focus on T-cell lymphoma, particularly systemic anaplastic large-cell lymphoma (sALCL) and cutaneous T-cell lymphoma (CTCL), as well as other peripheral T-cell lymphoma (PTCL) histologies. Areas covered: This review surveys current data on the efficacy of brentuximab vedotin in T-cell lymphoma, as well as embedding it in a therapeutic context by reviewing potential competitor agents in the clinic. Data are drawn from published literature, with a focus on clinical trial data rather than preclinical studies or case reports. Expert opinion: Brentuximab vedotin has a clear clinical benefit in CTCL and sALCL, and can achieve durable responses in a number of patients. Toxicities, particularly peripheral neuropathy, may limit treatment in some patients; however, the agent is generally well tolerated. In this context, brentuximab vedotin has been globally approved for use in sALCL and certain CTCL subtypes, however, further information is required to enhance our understanding of when and in whom to best employ this agent, as well as exploring rational combinations to augment responses.