Association of Crohn's Disease with Aryl Hydrocarbon Receptor Gene Polymorphisms in Patients from Southeast China

• Published in: Immunological investigations Vol. 48; no. 8; pp. 809 - 821
• Main Authors: Wu, Chao-qun, Lin, Qian-ru, Ying, Shi-jie, Luo, Jia-kai, Hong, Wei-jun, Lin, Zi-jian, Jiang, Yi
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.11.2019
• Subjects: Adult; Alleles; Aryl hydrocarbon receptor; Asian Continental Ancestry Group - genetics; Basic Helix-Loop-Helix Transcription Factors - genetics; China; Crohn Disease - ethnology; Crohn Disease - genetics; Crohn's disease; Female; gene; Gene Frequency; Genetic Predisposition to Disease - ethnology; Genetic Predisposition to Disease - genetics; Genotype; haplotype; Haplotypes; Humans; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Single Nucleotide; polymorphisms; Receptors, Aryl Hydrocarbon - genetics; Young Adult; China; Aryl hydrocarbon receptor; haplotype; gene; polymorphisms; Crohn’s disease
• ISSN: 0882-0139; 1532-4311
• DOI: 10.1080/08820139.2019.1569677

Aims The aryl hydrocarbon receptor (AhR) plays a pivotal role in regulating the innate and the acquired immune systems. The present study aimed to investigate the association of Crohn's disease (CD) with AhR polymorphisms in a cohort of patients from Southeast China. Methods An improved multiple ligase detection reaction technique was applied to examine the polymorphisms of rs2158041, rs2066853, and rs10249788 in 310 patients with CD and 573 controls. Results Compared to the controls, the variant allele (T) and genotype (CT+TT) of rs2158041 were less frequent in patients with CD (both p < 0.05). Similar conclusions were drawn from patients with ileal CD and with stricture CD as compared to the controls (all p < 0.0083). However, no significant differences were observed in allele and genotype frequencies of rs2066853 and rs10249788 between patients with CD and the controls (all p > 0.05). Although rs2158041 and rs10249788 were in complete linkage disequilibrium with rs2066853, respectively, only the frequency of haplotype (TG) formed by rs2158041 and rs2066853 was significantly lower in patients with CD than that in the controls (p < 0.05). Conclusions AhR (rs2158041) might be a susceptible locus for CD, especially for the two subtypes: ileal CD and stricture CD.