The effect of the modes of delivery on the maternal and neonatal dynamic thiol-disulfide homeostasis

• Published in: The journal of maternal-fetal & neonatal medicine Vol. 32; no. 23; p. 3993
• Main Authors: Ulubas Isik, Dilek, Akdaş Reis, Yıldız, Bas, Ahmet Yagmur, Unal, Sezin, Ozcan, Beyza, Mollamahmutoğlu, Leyla, Neselioglu, Salim, Erel, Özcan, Demirel, Nihal
• Format: Journal Article
• Language: English
• Published: England 02.12.2019
• Subjects: Adult; Delivery, Obstetric - adverse effects; Delivery, Obstetric - methods; Disulfides - blood; Female; Fetal Blood - chemistry; Homeostasis; Humans; Infant, Newborn; Male; Mothers; Oxidative Stress - physiology; Parturition - blood; Pregnancy; Prospective Studies; Sulfhydryl Compounds - blood; Young Adult; thiol–disulfide homeostasis; Mode of delivery; newborn
• ISSN: 1476-4954
• DOI: 10.1080/14767058.2018.1481028

Thiols are organic compounds containing sulfhydryl groups which exert antioxidant effects dynamic thiol-disulfide homeostasis. The shift towards disulfide indicates the presence of oxidative environment. The thiol-disulfide homeostasis has not been studied in different mode of delivery before. To investigate the effects of mode of parturition on the thiol-disulfide homeostasis in mothers and term infants. The participants were grouped according to the mode of their delivery: group vaginal delivery (VD,  = 40) and group cesarean section (C/S,  = 40). Three serum samples were collected: from mothers at the beginning of labor, from the cord blood (CB), and from the infants at the 24th hour after birth. The dynamic thiol-disulfide homeostasis in both groups were compared. The levels of native-thiol and total-thiol in CB were significantly higher in VD group than those with C/S group. The levels of disulfide were higher in infants born by C/S compared with those born by VD. The disulfide-to-native thiol ratio, disulfide-to-total thiol ratio, and native thiol-to-total thiol ratio were similar between two groups. Our results showed that the dynamic thiol-disulfide homeostasis of the neonate was greatly influenced by the way of delivery and supported that vaginally delivered infants have less oxidative stress.