Some sulfonamides as aldose reductase inhibitors: therapeutic approach in diabetes

In this study, aldose reductase (AR) was purified from sheep kidney using chromatographic methods and examined the interactions between some sulfonamides and the enzyme. According to results, sulfonamides display effective inhibitor features for sheep kidney AR with IC 50 values in the range of 37.2...

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Bibliographic Details
Published inArchives of physiology and biochemistry Vol. 128; no. 4; pp. 979 - 984
Main Authors Demir, Yeliz, Köksal, Zeynep
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 04.07.2022
Subjects
aldose reductase
enzyme inhibition
Enzyme purification
oxidative stress
sulfonamides
aldose reductase
sulfonamides
Enzyme purification
enzyme inhibition
oxidative stress
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Summary:In this study, aldose reductase (AR) was purified from sheep kidney using chromatographic methods and examined the interactions between some sulfonamides and the enzyme. According to results, sulfonamides display effective inhibitor features for sheep kidney AR with IC 50 values in the range of 37.27-87.65 μM and K i s in the range of 25.72 ± 6.45 to 73.56 ± 17.49 μM. The sulfonamides displayed different inhibition mechanisms. It was found that studied all compounds displayed non-competitive inhibition type except for 5-chlorothiophene-2-sulfonamide (1). It showed competitive inhibition. Among these compounds, 2,5-dichlorothiophene-3-sulfonamide compound (2) was showed the most potent AR inhibitor (K i : 25.72 ± 6.45). These compounds may be useful in the treatment of diabetic complications.
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ISSN:1381-3455
1744-4160
DOI:10.1080/13813455.2020.1742166