The correlation of immunologic derangement and juvenile recurrent parotitis: an investigation of the laboratory immunological observation

• Published in: Acta oto-laryngologica Vol. 138; no. 12; pp. 1112 - 1116
• Main Authors: Wu, Shufeng, Shi, Huan, Cao, Ningning, Ye, Lei, Yu, Chuangqi, Zheng, Lingyan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.12.2018
• Subjects: Adolescent; Age Factors; Analysis of Variance; Case-Control Studies; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Child; Child, Preschool; China; Female; Hospitals, Public; Humans; immune function; Immunoglobulin A - analysis; Immunoglobulin A - immunology; Immunoglobulin G - analysis; Immunoglobulin G - immunology; immunologic derangement; Juvenile recurrent parotitis; Male; Parotid Gland - immunology; Parotitis - diagnosis; Parotitis - immunology; Prognosis; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Factors; China; Juvenile recurrent parotitis; immune function; immunologic derangement
• ISSN: 0001-6489; 1651-2251
• DOI: 10.1080/00016489.2018.1515498

Background: Juvenile recurrent parotitis (JRP) is defined as recurrent parotid inflammation, generally associated with nonobstructive sialectasis of the parotid gland. In addition, the etiology remains unclear, probably immunologically mediated. Aim: The purposes of the present study were to report the relationship between JRP and immune function from the measurement of the JRP patients' immunoglobulins and T-lymphocyte subset. Methods: Immunologic assay from 2014 to 2017 of 100 children diagnosed with JRP at Shanghai Ninth Hospital compared with the 100 normal children by age. Results: The CD4 level of JRP children aged >6 years was significant lower than the one of JRP preschool children (p < .05), while the IgG level was significant higher than the one of the JRP preschool children (p < .05). In comparison with the normal children, the value of CD8 T cells, immunoglobulin G (IgG), immunoglobulin E (IgE), immunoglobulin A (IgA) and C3 (p < .01) of JRP children was significant higher, while the value of CD4 T cells was lower (p < .01) in spite of age. What is more, the value of CD8 T cells of JRP preschool children was much significant higher than the one of the normal preschool children (p < .01). Conclusion: The immune function of JRP patients may become disorder: the suppression cellular immune function and inadequate humoral immune expression.