Treatment facility volume and patient outcomes in Waldenstrom macroglobulinemia

Waldenstrom macroglobulinemia (WM) has an annual incidence of 3-3.2 cases per million-person/year. National Cancer Data Base was used to identify newly diagnosed WM cases requiring initiation of therapy and their annual facility volume was used to divide the treatment facilities into four quartiles...

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Published inLeukemia & lymphoma Vol. 62; no. 2; pp. 308 - 315
Main Authors Gunaratne, Madugodaralalage D. S. K., Sahakian, Alexander J., Abeykoon, Jithma P., Ansell, Stephen M., Gertz, Morie A., Kapoor, Prashant, Paulus, Aneel, Ailawadhi, Sikander, Reeder, Craig B., Witzig, Thomas E., Habermann, Thomas M., Novak, Anne J., Lacy, Martha Q., Kyle, Robert A., Go, Ronald S., Paludo, Jonas
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 28.01.2021
Subjects
academic center
Databases, Factual
Humans
Incidence
Lymphoplasmacytic lymphoma
non-Hodgkin lymphoma
patient volume
Risk Factors
survival
Waldenstrom Macroglobulinemia - diagnosis
Waldenstrom Macroglobulinemia - epidemiology
Waldenstrom Macroglobulinemia - therapy
patient volume
non-Hodgkin lymphoma
Lymphoplasmacytic lymphoma
academic center
survival
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Summary:Waldenstrom macroglobulinemia (WM) has an annual incidence of 3-3.2 cases per million-person/year. National Cancer Data Base was used to identify newly diagnosed WM cases requiring initiation of therapy and their annual facility volume was used to divide the treatment facilities into four quartiles (Qs). Cox regression was used to analyze the association between facility volume and survival, adjusted by demographics, socioeconomic, geographic, comorbidity factors and year of diagnosis. A total of 3064 patients treated in 795 facilities were included. The unadjusted median overall survival (OS) by facility volume was: Q1:6.5 years (5-year OS 55%), Q2:7 years (5-year OS 60%), Q3:8 years (5-year OS 64%), and Q4: NR (5-year OS 71%), p < 0.0001. Our results demonstrated that a volume-outcome relationship exists in WM and is an independent predictor of overall survival in addition to the established risk factors as age and disease severity.
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ISSN:1042-8194
1029-2403
DOI:10.1080/10428194.2020.1832669