Spatial consistency of co-exposure to air and surface water pollution and cancer in China

• Published in: Nature communications Vol. 15; no. 1; pp. 7813 - 12
• Main Authors: Jiang, Jingmei, Zhang, Luwen, Wang, Zixing, Gu, Wentao, Yang, Cuihong, Shen, Yubing, Zhao, Jing, Han, Wei, Hu, Yaoda, Xue, Fang, Chen, Wangyue, Guo, Xiaobo, Li, Hairong, Wu, Peng, Chen, Yali, Zhao, Yujie, Du, Jin, Jiang, Chengyu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.09.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/158/1469; 631/67/2324; 692/499; 692/700/478; 706/689/680; Air Pollutants - adverse effects; Air Pollutants - analysis; Air pollution; Air Pollution - adverse effects; Air Pollution - analysis; Cancer; China - epidemiology; Development policy; Environmental Exposure - adverse effects; Environmental governance; Environmental hazards; Environmental research; Evaluation; Exposure; Health risks; Humanities and Social Sciences; Humans; Incidence; Medical research; multidisciplinary; Neoplasms - chemically induced; Neoplasms - epidemiology; Neoplasms - etiology; Science; Science (multidisciplinary); Surface water; Water pollution; Water Pollution - adverse effects; China
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-024-52065-3

Humans can be exposed to multiple pollutants in the air and surface water. These environments are non-static, trans-boundary and correlated, creating a complex network, and significant challenges for research on environmental hazards, especially in real-world cancer research. This article reports on a large study (377 million people in 30 provinces of China) that evaluated the combined impact of air and surface water pollution on cancer. We formulate a spatial evaluation system and a common grading scale for co-pollution measurement, and validate assumptions that air and surface water environments are spatially connected and that cancers of different types tend to cluster in areas where these environments are poorer. We observe “dose–response” relationships in both the number of affected cancer types and the cancer incidence with an increase in degree of co-pollution. We estimate that 62,847 (7.4%) new cases of cancer registered in China in 2016 were attributable to air and surface water pollution, and the majority (69.7%) of these excess cases occurred in areas with the highest level of co-pollution. The findings clearly show that the environment cannot be considered as a set of separate entities. They also support the development of policies for cooperative environmental governance and disease prevention. Dissecting the associations between exposure to environmental pollution and cancer risk remains crucial. Here, the authors evaluate the impact of air and water pollution on cancer incidence in China using a spatial evaluation system and show that most excess cancer cases occurred in areas with the highest level of co-pollution.