Durability of antibodies post vaccination with two doses of inactivated BBIBP-CorV vaccine

• Published in: Current medical research and opinion Vol. 38; no. 12; p. 2069
• Main Authors: Mahmoud, Sally, Ganesan, Subhashini, Sharif-Askari, Narjes Saheb, Cantarutti, Flavia, Wilson, Hannah, Ogrodzki, Pauline, Halwani, Rabih, Alkaabi, Nawal, Zaher, Walid Abbas
• Format: Journal Article
• Language: English
• Published: England 02.12.2022
• Subjects: Antibodies, Neutralizing; COVID-19; COVID-19 Vaccines; Humans; Immunoglobulin G; Infant; Male; Retrospective Studies; Vaccination; COVID-19; SARS-CoV-2; BBIBP-CorV; IgG; UAE; neutralizing antibodies; inactivated vaccines; retrospective study
• ISSN: 1473-4877
• DOI: 10.1080/03007995.2022.2139969

Breakthrough infections post-COVID-19 vaccination occur with the emerging variants of the SARS-CoV virus which might be either due to the newer variants escaping immune response or the waning of antibodies over time. However, there is lack of long-term follow-up evidence on the waning of immune response following inactivated COVID-19 vaccine. A retrospective, observational study was conducted on serum samples of individuals who had received two doses of BBIBP-CorV vaccine. Individual's antibody responses were evaluated based on IgG anti-S and neutralizing antibodies measurements. Antibody samples were categorized into four groups, defined by the time interval from the individual's receipt of the BBIBP-CorV vaccine: <30 days, 30-90 days, 91-180 days and >180 days. A total of 6668 serum samples from inactivated BBIBP-CorV vaccine recipients were analyzed for IgG anti-S and neutralizing antibodies. 571 (8.6%) samples were tested during the first 29 days interval post vaccination, 3642 (54.6%) were tested during 30-90 days interval, 2173 (32.6%) samples were tested during 91 to 180 days interval and 282(4.2%) were tested at >180 days interval post vaccination. We found that more than 50% of the individuals had antibody titers below the average cut-off range at the 91-180 days interval post vaccination. Older age (>60 years), male gender, chronic kidney disease, hypertension, immunodeficiencies and increased interval post vaccination emerged as independent risk factors associated with lower immune response. Inactivated BBIBP-CorV vaccine recipients, based on age, gender and associated comorbid conditions might need booster doses at an earlier interval than the currently followed six months interval.