Serum CYR61 Is Associated with Disease Activity in Graves' Orbitopathy

• Published in: Ocular immunology and inflammation Vol. 26; no. 7; pp. 1094 - 1100
• Main Authors: Woo, Young Jun, Seo, Yuri, Kim, Jin Joo, Kim, Ji Won, Park, Yil, Yoon, Jin Sook
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.10.2018
• Subjects: Adipose Tissue - metabolism; Adult; Aged; Biomarker; Biomarkers - blood; Case-Control Studies; CCN1; CYR61; Cysteine-Rich Protein 61 - blood; Cysteine-Rich Protein 61 - genetics; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression - physiology; Genetic Markers; Graves Ophthalmopathy - blood; Graves Ophthalmopathy - genetics; Humans; inflammation; Male; Middle Aged; Orbit - metabolism; Polymerase Chain Reaction; RNA, Messenger - genetics; thyroid ophthalmopathy; Young Adult; Biomarker; thyroid ophthalmopathy; CCN1; inflammation; CYR61
• ISSN: 0927-3948; 1744-5078
• DOI: 10.1080/09273948.2017.1319960

Purpose: To investigate the clinical implications of cysteine-rich angiogenic inducer 61 (CYR61) in Graves' orbitopathy (GO). Methods: Sera from 52 GO patients, 23 Graves' disease (GD) patients, and 20 healthy controls, and orbital fat tissue samples from 12 of 52 GO patients and 8 control subjects were included for analysis. Concentrations of CYR61 were measured from sera with an enzyme-linked immunosorbent assay, and CYR61 mRNA expression levels were evaluated from orbital fat tissue with polymerase chain reaction. Results: Serum CYR61 levels were higher in GO patients than in controls (p = 0.001). Patients with active GO showed higher CYR61 levels than those with inactive GO (p < 0.001) or GD (p = 0.004). Expression of CYR61 mRNA was 7.4-fold higher in patients with GO than in healthy controls (p < 0.001). Conclusions: CYR61 could be an adjuvant biomarker associated with the inflammatory activity of GO.