Immunostaining characteristics of irisin in benign and malignant renal cancers

We investigated the expression of irisin in renal cancers using immunocytochemistry. Irisin has been reported to exhibit anticancer properties. The study groups consisted of 22 cases each of control renal tissue, oncocytoma, chromophobe renal cell carcinoma (RCC), clear cell RCC (Fuhrman nuclear gra...

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Published inBiotechnic & histochemistry Vol. 94; no. 6; pp. 435 - 441
Main Authors Kuloğlu, T., Artaş, G., Yardim, M., Sahin, i., Aydin, Y., Beyoğlu, N., Özercan, İ. H., Yalcin, M. H., Ugur, K., Aydin, S.
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 18.08.2019
Subjects
Adenoma, Oxyphilic - diagnosis
Adenoma, Oxyphilic - pathology
Algorithms
Biomarkers, Tumor - analysis
Cancer
Carcinoma, Renal Cell - diagnosis
Carcinoma, Renal Cell - pathology
chromophobe RCC
clear cell RCC
Diagnosis, Differential
Fibronectins - metabolism
Fuhrman nuclear grade
Humans
Immunohistochemistry - methods
irisin
Kidney Neoplasms - diagnosis
Kidney Neoplasms - pathology
oncocytoma
renal tissue
clear cell RCC
oncocytoma
renal tissue
chromophobe RCC
irisin
Fuhrman nuclear grade
Cancer
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Summary:We investigated the expression of irisin in renal cancers using immunocytochemistry. Irisin has been reported to exhibit anticancer properties. The study groups consisted of 22 cases each of control renal tissue, oncocytoma, chromophobe renal cell carcinoma (RCC), clear cell RCC (Fuhrman nuclear grades 1, 2, 3 and 4) and papillary RCC. We evaluated 10 slides for each of 176 cases. Slides were immunostained for irisin and histoscores were calculated for the prevalence and strength of immunostaining. Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC exhibited no irisin immunoreactivity. Irisin immunoreactivity was observed in some Fuhrman nuclear grade 4 RCCs. We found a significant decrease in irisin staining in chromophobe RCC compared to the control. Immunoreactivity in the oncocytoma tissue was comparable to the control group. Irisin immunoreactivity in chromophobe RCC decreased and no immunoreactivity was observed in Fuhrman nuclear grade 1, 2, 3 clear cell RCC and papillary RCC. Immunistochemical screening of irisin in renal oncocytomas and renal cancers may be useful for differential diagnosis.
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ISSN:1052-0295
1473-7760
DOI:10.1080/10520295.2019.1586998