Use of asprosin and subfatin for differential diagnosis of serous ovarian tumors

• Published in: Biotechnic & histochemistry Vol. 98; no. 2; pp. 140 - 146
• Main Authors: Mirzaoglu, Miyase, Yavuzkir, Seyda, Mirzaoglu, Cetin, Yurt, Nurdan, Dagli, Adile Ferda, Ozcan Yildirim, Sena, Sahin, İbrahim, Aydin, Suleyman
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.02.2023
• Subjects: Asprosin; Biomarkers, Tumor - analysis; Diagnosis, Differential; Female; Humans; meteorin-like protein; metrnl; Ovarian Neoplasms - diagnosis; Ovarian Neoplasms - metabolism; serous ovarian cancer; subfatin; serous ovarian cancer; subfatin; meteorin-like protein; metrnl; Asprosin
• ISSN: 1052-0295; 1473-7760
• DOI: 10.1080/10520295.2022.2135763

Asprosin (ASP) and subfatin are hormones that regulate glucose metabolism. The role of ASP and subfatin in serous ovarian tumors has not been investigated. We investigated the expression of subfatin and asprosin in 30 serous benign, 30 serous borderline, 30 malignant and 30 control ovarian tissues. We investigated ASP and subfatin immunoreactivity and quantification was achieved using an ELISA method. ASP and subfatin were localized in the epithelial parts of normal ovarian tissues; however, in cancer tissues, immunoreactivity was detected in the parenchymal areas. Biochemical analysis of ovarian tissues revealed significantly decreased ASP and subfatin compared to the control. We propose that ASP and subfatin are promising candidates for biomarkers to distinguish serous benign, serous borderline and malignant ovarian cancers.