Prevalence, clinical characteristics, and long-term outcomes of new diabetes diagnosis in elderly patients undergoing percutaneous coronary intervention

• Published in: Scientific reports Vol. 14; no. 1; pp. 14814 - 9
• Main Authors: Xue, Zheng-Kai, Dai, Xin-Ya, Ren, Jia-Yi, Liu, Tong, Zhang, Yu-Kun, Hu, Su-Tao, Wang, Peng, Wu, Xue, Zhang, Jing-Kun, Tse, Gary, Park, Soohyung, Choi, Cheol-Ung, Choi, Byoung-Geol, Rha, Seung-Woon, Chen, Kang-Yin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.06.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 692/163/2743/137/773; 692/4019/2776; 692/499; Aged; Aged, 80 and over; Angioplasty; Coronary artery disease; Diabetes; Diabetes mellitus; Diabetes Mellitus - epidemiology; Diagnosis; Elderly; Female; Humanities and Social Sciences; Humans; Male; multidisciplinary; Myocardial infarction; Newly diagnosed diabetes; Patients; Percutaneous coronary intervention; Percutaneous Coronary Intervention - adverse effects; Prevalence; Proportional Hazards Models; Prospective Studies; Republic of Korea - epidemiology; Risk Factors; Science; Science (multidisciplinary); Treatment Outcome; Republic of Korea; Percutaneous coronary intervention; Newly diagnosed diabetes; Elderly; Coronary artery disease
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-65426-1

Previous studies have reported associations between newly diagnosed diabetes and poor outcomes after percutaneous coronary intervention (PCI), but there is limited data focusing on elderly patients (age ≥ 65). This study aimed to analyze the prevalence and clinical implications of newly diagnosed diabetes in elderly patients who underwent PCI. From 2004 to 2021, a total of 2456 elderly patients who underwent invasive PCI at Korea University Guro Hospital were prospectively enrolled and followed up for a median of five years. The primary endpoint was five-year major adverse cardiovascular events (MACE). Cox regression was used to evaluate whether newly diagnosed diabetes impacted on long-term clinical outcomes. Newly diagnosed diabetes was presented in approximately 8.1% to 10.9% of elderly patients who underwent PCI. Those who had a new diagnosis of diabetes had a higher risk of MACE than previously known diabetes (25.28% vs. 19.15%, p  = 0.039). After adjusting for significant factors, newly diagnosed diabetes remained an independent predictor of MACE (HR [hazard ratio] 1.64, 95% confidence interval [CI] 1.24–2.17, p  < 0.001), cardiac death (HR 2.15, 95% CI 1.29–3.59, p  = 0.003) and repeat revascularization (HR 1.52, 95% CI 1.09–2.11, p  = 0.013), but not for non-fatal myocardial infarction (HR 1.66, 95% CI 0.94–2.12, p  = 0.081). Newly diagnosed diabetes was associated with an increased risk of 5-year MACE compared with non-diabetes and previously diagnosed diabetes in elderly patients underwent PCI. More attention should be given to those elderly newly diagnosed diabetes population.