3D Z-scheme conjugated polymer/Cu2O for organic photoelectrochemical transistor bioassay

• Published in: Biosensors & bioelectronics Vol. 268; p. 116877
• Main Authors: Wang, Cheng-Shuang, Chen, Jia-Hao, Zhang, Pan-Ke, Yuan, Cheng, Yu, Si-Yuan, Zhao, Wei-Wei, Xu, Jing-Juan
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.01.2025
• Subjects: antigens; Bioassay; bioassays; biosensors; Conjugated polymers; detection limit; Organic photoelectrochemical transistor; transistors; Z-scheme heterojunction; Conjugated polymers; Organic photoelectrochemical transistor; Bioassay; Z-scheme heterojunction
• ISSN: 0956-5663; 1873-4235; 1873-4235
• DOI: 10.1016/j.bios.2024.116877

Organic photoelectrochemical transistor (OPECT) is an emerging technology studying photo-electric-biological recognition events. Here, this work reports the three-dimensional (3D) Z-scheme poly (1,4-diethynylbenzene) (pDEB)@Cu2O heterojunction as a high-efficacy photogating module and its application for OPECT bioassay. Specifically, 3D Z-scheme pDEB@Cu2O heterojunction enabled fast charge transport and ion diffusion in the system, achieving remarkable amplification capability with a current gain as high as ca. 9.6 × 103. By linking with GOx-labeled sandwich immunorecognition, the impact of GOx-generated H2O2 on the OPECT made possible the sensitive bioassay. Exemplified by carcinoembryonic antigen (CEA) as the model target, the OPECT device achieved a linear detection range spanning from 100 fg/mL to 100 ng/mL and coupled with a detection limit as low as 72 fg/mL. This work provided a generic and extensible platform for the designation of novel bioassay systems. [Display omitted]