Klebsiella pneumoniae Infection Leads to a Poor Visual Outcome in Endogenous Endophthalmitis: A 12-year Experience in Southern Taiwan

• Published in: Ocular immunology and inflammation Vol. 25; no. 6; pp. 870 - 877
• Main Authors: Chen, Shih-Chou, Lee, Ying-Yen, Chen, Ya-Hsin, Lin, Huey-Shyan, Wu, Tsung-Tien, Sheu, Shwu-Jiuan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.11.2017
• Subjects: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; Aqueous Humor - microbiology; Endogenous endophthalmitis; Endophthalmitis - diagnosis; Endophthalmitis - drug therapy; Endophthalmitis - microbiology; Eye Infections, Bacterial - diagnosis; Eye Infections, Bacterial - drug therapy; Eye Infections, Bacterial - microbiology; Female; Humans; Klebsiella Infections - diagnosis; Klebsiella Infections - drug therapy; Klebsiella Infections - microbiology; Klebsiella pneumoniae; Klebsiella pneumoniae - isolation & purification; liver abscess; Male; Middle Aged; prognosis; Retrospective Studies; Taiwan; Vision Disorders - microbiology; Visual Acuity; Vitreous Body - microbiology; liver abscess; prognosis; Endogenous endophthalmitis; Klebsiella pneumoniae; Taiwan
• ISSN: 0927-3948; 1744-5078
• DOI: 10.1080/09273948.2016.1193616

Purpose: To compare the characteristics, visual outcome, and prognostic factors of patients with endogenous endophthalmitis and to determine the association of endophthalmitis with Klebsiella pneumoniae infection. Methods: We retrospectively analyzed records of patients diagnosed with endogenous endophthalmitis from January 2002 to August 2013. Results: A total of 86 patients were diagnosed with endogenous endophthalmitis; 48 patients were infected with K. pneumoniae, 28 patients were infected with other pathogens, and 10 were culture-negative. Diabetes mellitus was more prevalent among patients infected with K. pneumoniae. Liver abscess and urinary tract infection were the leading sources of infection in patients with and without a K. pneumoniae infection, respectively. In patients with endogenous endophthalmitis, poor initial vision (p<0.001) and K. pneumoniae infection (p = 0.048) were significantly associated with a poor visual outcome. Conclusions: Poor initial vision and K. pneumoniae infection were significantly associated with poorer visual outcome for patients with endogenous endophthalmitis.