The Association Between VEGF +936C/T and −634G/C Polymorphisms and Breast Cancer Susceptibility, Tumor Growth, and Metastases: Evidence From 20,728 Subjects

• Published in: Cancer investigation Vol. 33; no. 7; pp. 312 - 317
• Main Authors: Ma, Jianguo, Hu, Weiguo, Zhang, Ping, Sun, Yujing, Wang, Na, Teng, Xiaoyan, Qiao, Qian
• Format: Journal Article
• Language: English
• Published: England Informa Healthcare 09.08.2015
• Subjects: Breast cancer; Breast Neoplasms - ethnology; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Case-Control Studies; Continental Population Groups - ethnology; Continental Population Groups - genetics; Female; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Meta-analysis; Neoplasm Metastasis; Polymorphism, Single Nucleotide; Polymorphisms; Vascular Endothelial Growth Factor A - genetics; VEGF; Breast cancer; Polymorphisms; VEGF; Meta-analysis
• ISSN: 0735-7907; 1532-4192; 1532-4192
• DOI: 10.3109/07357907.2015.1044664

The relation between the polymorphisms of vascular endothelial growth factor (VEGF) and breast cancer remains inconclusive. In our meta-analysis based on 10,340 breast cancer patients and 10,388 controls, we found breast cancer susceptibility was elevated in individuals carrying the VEGF +936C allele, especially in Asians, and the +936CC increases tumor growth. The G allele of -634G/C polymorphism reduces breast cancer susceptibility in Asians, and breast cancer patients of -634GG genotype has decreased tumor growth. These results suggest that both the VEGF +936C/T and -634G/C polymorphisms influence breast cancer susceptibility and tumor growth, instead of metastasis.