Obesity: Lifestyle management, bariatric surgery, drugs, and the therapeutic exploitation of gut hormones

Obesity is on the rise and the pursuit of efficient and safe treatment is ongoing. Available anti-obesity medical therapies have so far proved to be disappointing, whereas bariatric surgery is leading the way and offers long-term health benefits. Part of the success of bariatric surgery is thought t...

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Bibliographic Details
Published inPostgraduate medicine Vol. 127; no. 5; p. 494
Main Authors Behary, Preeshila, Cegla, Jaimini, Tan, Tricia M, Bloom, Stephen R
Format Journal Article
LanguageEnglish
Published England 03.09.2015
Subjects
Anti-Obesity Agents - therapeutic use
Bariatric Surgery
Gastrointestinal Hormones - physiology
Humans
Life Style
Obesity - therapy
lifestyle management
Obesity
bariatric surgery
drugs
gut hormones
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Summary:Obesity is on the rise and the pursuit of efficient and safe treatment is ongoing. Available anti-obesity medical therapies have so far proved to be disappointing, whereas bariatric surgery is leading the way and offers long-term health benefits. Part of the success of bariatric surgery is thought to be mediated by gut hormones. A better understanding of the role of gut hormones within the gut-brain signaling pathway in the control of hunger, satiety, and energy homeostasis, has led to their therapeutic exploitation as possible anti-obesity drugs. In this review, we provide a summary of currently available treatment options for obesity from simple lifestyle modifications and bariatric surgery to traditional and novel medical therapies.
ISSN:1941-9260
DOI:10.1080/00325481.2015.1048181