Effect of the increase rate of blood lipid concentration during pregnancy on the adverse pregnancy outcomes: a cohort study of 1051 singleton pregnancy

• Published in: Gynecological endocrinology Vol. 38; no. 12; pp. 1125 - 1128
• Main Authors: Yu, Xiaoping, Gao, Jinfeng, Huang, Yan, Zou, Yufei, Huang, Ying, Du, Tao, Zhang, Ju
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.12.2022
• Subjects: Adult; adverse pregnancy outcomes; blood lipid concentration; Child; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Diabetes, Gestational; Female; Humans; Lipids; Pregnancy; Pregnancy Outcome; Triglycerides; Young Adult; 不良妊娠结局; 血脂浓度; Pregnancy; adverse pregnancy outcomes; 血脂浓度; blood lipid concentration; 不良妊娠结局; 妊娠
• ISSN: 0951-3590; 1473-0766
• DOI: 10.1080/09513590.2022.2138314

To investigate the effects of blood lipid concentration and blood lipid growth rate in the first and third trimesters of pregnancy on adverse pregnancy outcomes. The study subjects were 1051 singleton pregnant women who established archives in Chengdu Maternity and Child Specialty Hospital. The pregnancy information was continuously recorded until the pregnant woman gave birth, and lipid biochemical indicators were performed every three months. The average age of the pregnant women recruited was 27.82 ± 3.07 years. Compared with the first trimester, the concentration of triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in the third trimester were increased significantly (all p < .05). The growth rate of triglyceride was closely related to the occurrence of gestational diabetes mellitus and large for gestational, and the growth rate of total cholesterol and low-density lipoprotein cholesterol was closely related to gestational diabetes mellitus and cholestasis of pregnancy. For every unit increase in triglyceride growth rate, the risk of gestational diabetes mellitus and large for gestational age increases by 1.237 times and 1.317 times, respectively. Among non-high-risk pregnant women, blood lipid concentration is generally high among pregnant women with complications during pregnancy. It is necessary to combine a single blood lipid test concentration during pregnancy with the blood lipid growth rate to assess the condition of pregnant women and provide better guidance during pregnancy.