Radioactive versus normal stent insertion for malignant hilar obstruction: a meta-analysis

• Published in: Minimally invasive therapy and allied technologies Vol. 32; no. 2; pp. 47 - 55
• Main Authors: Chen, Zhong-Ke, Li, Dong-Lu, Du, Jun-Jun, She, Jia-Xiang, Meng, Jiao, Fan, Jing
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.04.2023
• Subjects: Bile Duct Neoplasms; biliary; Cholecystitis - complications; Cholestasis - complications; Cholestasis - surgery; hilar; Humans; normal stent; Radioactive stent; Stents; Treatment Outcome; Radioactive stent; biliary; hilar; normal stent
• ISSN: 1364-5706; 1365-2931; 1365-2931
• DOI: 10.1080/13645706.2022.2164697

This meta-analysis was designed for examining the relative clinical safety and efficacy of normal stent (NS) and radioactive stent (RS) insertion in malignant hilar obstruction (MHO) patients. Relevant studies published as of March 2022 were identified through searches of the Medline, Embase, Wanfang, and CNKI databases, and the pooled results of these studies were then analyzed. Eight studies including 258 and 247 patients that underwent NS and RS insertion, respectively, were incorporated into this meta-analysis. RS insertion was found to be associated with significant improvements in functional successful rate (p = 0.04), Δaspertate aminotransferase (AST, p = 0.0004), Δalanine aminotransferase (ALT, p = 0.002), stent patency (p < 0.00001), stent re-obstruction rate (p = 0.03), and OS (p < 0.00001) outcomes as compared to those associated with NS insertion. No differences in Δtotal bilirubin (TBIL, p = 0.38), cholangeitis rate (p = 0.45), cholecystitis rate (p = 0.84), or hemorrhage rate (p = 0.87) were observed when comparing patients that underwent RS and NS insertion. Substantial publication bias was observed for endpoints of cholecystitis and hemorrhage. These results suggest that relative to NS insertion, RS insertion can effectively prolong stent patency and OS in MHO cases.