Platelet-Rich Plasma (PRP) and Injectable Platelet-Rich Fibrin (i-PRF) in the Non-Surgical Treatment of Periodontitis-A Systematic Review

• Published in: International journal of molecular sciences Vol. 25; no. 12; p. 6319
• Main Authors: Niemczyk, Wojciech, Janik, Katarzyna, Żurek, Jacek, Skaba, Dariusz, Wiench, Rafał
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.06.2024; MDPI
• Subjects: Bias; Blood platelets; Cell adhesion & migration; Debridement; Gum disease; Humans; Injections; Insulin-like growth factors; periodontics; periodontitis; Periodontitis - therapy; Plasma; platelet-rich fibrin; Platelet-Rich Fibrin - metabolism; Platelet-Rich Plasma; Review; root planing; Root Planing - methods; Systematic review; injections; dental scaling; blood platelets; periodontal debridement; periodontitis; periodontics; platelet-rich fibrin; platelet-rich plasma; root planing
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25126319

The gold standard in the non-surgical treatment of periodontitis is scaling and root planing (SRP). In recent years, the use of autogenous platelet concentrates has spread over many specialties in dentistry and, thus, has also been gaining popularity in periodontal treatment. Its two main fractions are platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), which, since 2014, can also be used via injection as injectable platelet-rich fibrin (i-PRF). The authors conducted a comprehensive systematic review in accordance with the PRISMA 2020 guidelines. It involved searching PubMed, Embase, Scopus, and Google Scholar databases using the phrases ("Root Planing" OR "Subgingival Curettage" OR "Periodontal Debridement") AND ("Platelet-Rich Plasma"). Based on the authors' inclusion and exclusion criteria, 12 results were included in the review, out of 1170 total results. The objective of this review was to ascertain the impact of utilizing PRP and i-PRF in SRP. The results revealed that both the incorporation of PRP and i-PRF were found to be significantly associated with are duction in gingival pocket depth and again in clinical attachment level; however, i-PRF demonstrated superiority in improving clinical parameters. Furthermore, i-PRF demonstrated notable bactericidal efficacy against . On the other hand, PRP proved inferior to an Nd:YAG laser in clinical parameter improvement; however, it demonstrated significant efficiency as well. This literature review led the authors to the conclusion that autologous platelet concentrates might be competent agents for improving the therapeutic outcomes of SRP.