Polymorphisms in the MTHFR and MTR genes and the risk of varicose veins in ethnical Russians

• Published in: Biomarkers Vol. 21; no. 7; pp. 619 - 624
• Main Authors: Shadrina, Alexandra Sergeevna, Sevost'ianova, Kseniya Sergeevna, Shevela, Andrey Ivanovich, Soldatsky, Evgenii Yurievich, Seliverstov, Evgenii Igorevich, Demekhova, Marina Yurievna, Shonov, Oleg Aleksandrovich, Ilyukhin, Evgenii Arkadievich, Smetanina, Mariya Aleksandrovna, Voronina, Elena Nikolaevna, Pikalov, Ilya Victorovich, Zolotukhin, Igor Anatolyevich, Filipenko, Maxim Leonidovich
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.10.2016
• Subjects: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics; Association; Ethnic Groups; folate-metabolizing genes; Genetic Predisposition to Disease - genetics; Genotype; Humans; Inheritance Patterns - genetics; Logistic Models; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Polymorphism, Single Nucleotide; Russia; SNP; Varicose Veins - genetics; SNP; folate-metabolizing genes; Association
• ISSN: 1354-750X; 1366-5804; 1366-5804
• DOI: 10.3109/1354750X.2016.1171902

Objectives: The objective of this study was to study the association of polymorphisms MTHFR C677T (rs1801133) and MTR A2756G (rs1805087) with the risk of varicose veins in ethnical Russians. Methods: We genotyped 475 patients with varicose veins, 168 individual without chronic venous disease, and the population-based group of 896 subjects. Association was studied using logistic regression analysis adopting co-dominant, additive, recessive, and dominant models of inheritance. Results: None of the polymorphisms showed a statistically significant association with the risk of varicose veins. Conclusions: Our results provide evidence that the studied polymorphisms do not contribute to genetic susceptibility to varicose veins in ethnical Russians.