Pharmacogenetics and drug metabolism: historical perspective and appraisal

The events leading up to the discovery of genetically controlled polymorphic metabolism of xenobiotics and pharmaceutical chemicals are briefly summarised with the salient historical features being emphasised. Especial attention has been given to seminal works in the then emerging field. The evolvin...

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Bibliographic Details
Published inXenobiotica Vol. 50; no. 1; pp. 3 - 8
Main Authors Smith, Robert L., Mitchell, Stephen C.
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 02.01.2020
Subjects
drug metabolism
genotype
Inactivation, Metabolic
Metabolic Clearance Rate
personalized medicine
Pharmacogenetics
phenotype
Xenobiotics - metabolism
phenotype
Pharmacogenetics
drug metabolism
genotype
personalized medicine
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Summary:The events leading up to the discovery of genetically controlled polymorphic metabolism of xenobiotics and pharmaceutical chemicals are briefly summarised with the salient historical features being emphasised. Especial attention has been given to seminal works in the then emerging field. The evolving knowledge of such polymorphic metabolism and its role in the quest for personalised medicine and the individualisation of patient drug therapy are appraised. Opinion is offered as to whether or not the full potential has been exploited and if the practical application of this information may be regarded as a success or failure within the present clinical arena.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0049-8254
1366-5928
DOI:10.1080/00498254.2019.1668579