MiRNAs roles in the diagnosis, prognosis and treatment of colorectal cancer

: The liver is the main location for metastasization in stage IV colorectal cancers. : This review intends to comprehensively present the most important studies conducted in the past few years concerning the role of miRNAs in colorectal cancer liver metastases, trying to clarify some aspects regardi...

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Published inExpert review of proteomics Vol. 16; no. 10; p. 851
Main Authors Sur, Daniel G, Colceriu, Marius, Sur, Genel, Aldea, Cornel, Silaghi, Ciprian, Samasca, Gabriel, Lupan, Iulia, Căinap, Călin, Burz, Claudia, Irimie, Alexandru
Format Journal Article
LanguageEnglish
Published England 03.10.2019
Subjects
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colorectal cancer
prognostic indicators
treatment stratification
liver metastases
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Summary:: The liver is the main location for metastasization in stage IV colorectal cancers. : This review intends to comprehensively present the most important studies conducted in the past few years concerning the role of miRNAs in colorectal cancer liver metastases, trying to clarify some aspects regarding tumor biology and favorite liver metastasization site. : Recent advances in tissue and serum RNA extraction has considerably improved the field of microRNAs studies. These molecules known to play a crucial role in the metastatic stage indicate a starting point in the development of clinical biomarkers with a possible role in the stratification of high-risk patients for adequate treatment.
ISSN:1744-8387
DOI:10.1080/14789450.2019.1659732