UGT1A128 gene polymorphism was not associated with the risk of neonatal hyperbilirubinemia: a meta-analysis

• Published in: The journal of maternal-fetal & neonatal medicine Vol. 34; no. 24; p. 4064
• Main Authors: Li, Hongjuan, Zhang, Piqiang
• Format: Journal Article
• Language: English
• Published: England 17.12.2021
• Subjects: Genetic Predisposition to Disease; Glucuronosyltransferase - genetics; Humans; Hyperbilirubinemia, Neonatal - genetics; Infant, Newborn; Odds Ratio; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Reproducibility of Results; meta-analysis; UGT1A128; Gene polymorphism; neonatal hyperbilirubinemia
• ISSN: 1476-4954
• DOI: 10.1080/14767058.2019.1702962

This study aimed to evaluate the relationship between UGT1A1*28 gene polymorphism and the risk of neonatal hyperbilirubinemia (NHBI). The studies meet certain selection condition which was obtained from databases such as PubMed, Embase, and Cochrane Library. Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of included studies. Meta-analysis was performed according to criteria such as country. Hardy-Weinberg's equilibrium (HWE) tests were performed on the control group using chi-square test, while the evaluation index was represented by odds ratio (OR) and 95% confidence interval (CI). Egger's test and sensitivity analysis were used to evaluate the publication bias and reliability, repetitively. Totally, four studies with high overall quality were enrolled in this study. No association was observed between UGT1A1*28 gene polymorphisms and NHBI in allele model (TA7 versus TA6, OR (95% CI) = 2.13 (0.81-5.62),  = .13), codominance models (TA7/6 versus TA6/6, OR (95% CI) = 2.94 (0.90-9.57),  = .07; TA7/7 versus TA6/6, OR (95% CI) = 2.08 (0.37-11.52),  = .40), recessive model (TA7/7 versus TA6/6 + TA7/6, OR (95% CI) = 1.44 (0.41-5.14),  = .57), and dominant model (TA7/7 + TA7/6 versus TA6/6, OR (95% CI) = 2.92 (0.84-10.12),  = .09). Furthermore, there was no publication bias found in current meta-analysis. Gene polymorphism of UGT1A1*28 might not be associated with the risk of NHBI.