Metal-free C-3 selective C(sp 2 )-C(sp 3 ) heteroarylation of anilines with imidazo[1,2- a ]pyridine derivatives via cross-dehydrogenative coupling

A general and straightforward method for the regioselective construction of C-3 heteroaryl-containing imidazo[1,2- ]pyridines cross-dehydrogenative coupling under transition-metal-free conditions has been reported, utilizing , -dimethylaniline as the methylenation source and furnishing the C(sp )-C(...

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Bibliographic Details
Published inRSC advances Vol. 13; no. 31; pp. 21685 - 21689
Main Authors Wang, Kai, Du, Xiaoxue, Zhang, Pengfei, Wei, Zhenjiang, Cao, Xian-Ting
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 12.07.2023
The Royal Society of Chemistry
Subjects
Aniline
Chemistry
Coupling
Dehydrogenation
Pyridines
Transition metals
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Summary:A general and straightforward method for the regioselective construction of C-3 heteroaryl-containing imidazo[1,2- ]pyridines cross-dehydrogenative coupling under transition-metal-free conditions has been reported, utilizing , -dimethylaniline as the methylenation source and furnishing the C(sp )-C(sp ) functionalized products in good to excellent yields. Mechanism studies indicate that a radical pathway is responsible for this transformation.
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ISSN:2046-2069
2046-2069
DOI:10.1039/d3ra03852a